Literature DB >> 3732493

The potent tremorgenic neurotoxins lolitrem B and aflatrem: a comparison of the tremor response in mice.

R T Gallagher, A D Hawkes.   

Abstract

Tremor dose-response curves were determined for mice dosed with the ryegrass neurotoxin lolitrem B, and the tremor-genic mycotoxin aflatrem. A family of characteristic curves was revealed for each tremorgenic, with lolitrem B eliciting a sustained tremor response persisting for over 24 h.

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Year:  1986        PMID： 3732493     DOI： 10.1007/bf01941539

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  13 in total

1.  Aflatrem, the tremorgenic mycotoxin from Aspergillus flavus.

Authors:  R T Gallagher; B J Wilson
Journal:  Mycopathologia       Date:  1979-02-28       Impact factor: 2.574

2.  Ryegrass staggers: the presence of lolitrem neurotoxins in perennial ryegrass seed.

Authors:  R T Gallagher; A G Campbell; A D Hawkes; P T Holland; D A McGaveston; E A Pansier; I C Harvey
Journal:  N Z Vet J       Date:  1982-11       Impact factor: 1.628

3.  Mechanisms of tremor induction by harmine.

Authors:  D M Kelly; R J Naylor
Journal:  Eur J Pharmacol       Date:  1974-06       Impact factor: 4.432

4.  High-performance liquid chromatography with stop-flow ultraviolet spectral characterization of lolitrem neurotoxins from perennial ryegrass.

Authors:  R T Gallagher; A D Hawkes
Journal:  J Chromatogr       Date:  1985-03-29

5.  Rapid determination of the neurotoxin lolitrem B in perennial ryegrass by high-performance liquid chromatography with fluorescence detection.

Authors:  R T Gallagher; A D Hawkes; J M Stewart
Journal:  J Chromatogr       Date:  1985-03-08

6.  Ryegrass staggers: isolation of potent neurotoxins lolitrem A and lolitrem B from staggers-producing pastures.

Authors:  R T Gallagher; E P White; P H Mortimer
Journal:  N Z Vet J       Date:  1981-10       Impact factor: 1.628

7.  Isolation of potentially tremorgenic fungi from pasture associated with a condition resembling ryegrass staggers.

Authors:  B J Shreeve; D S Patterson; B A Roberts; S M MacDonald; E N Wood
Journal:  Vet Rec       Date:  1978-09-02       Impact factor: 2.695

8.  Intoxication of horses by lolitrem B in ryegrass seed cleanings.

Authors:  B L Munday; I M Monkhouse; R T Gallagher
Journal:  Aust Vet J       Date:  1985-06       Impact factor: 1.281

9.  TOXIN FROM ASPERGILLUS FLAVUS: PRODUCTION ON FOOD MATERIALS OF A SUBSTANCE CAUSING TREMORS IN MICE.

Authors:  B J WILSON; C H WILSON
Journal:  Science       Date:  1964-04-10       Impact factor: 47.728

10.  Production of tremorgenic toxins by Penicillium janthinellum Biourge: a possible aetiological factor in ryegrass staggers.

Authors:  G W Lanigan; A L Payne; P A Cockrum
Journal:  Aust J Exp Biol Med Sci       Date:  1979-02
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  8 in total

Review 1.  Lolitrem B and Indole Diterpene Alkaloids Produced by Endophytic Fungi of the Genus Epichloë and Their Toxic Effects in Livestock.

Authors:  Guerre Philippe
Journal:  Toxins (Basel)       Date:  2016-02-15       Impact factor: 4.546

2.  Genetic Underpinnings of Host Manipulation by Ophiocordyceps as Revealed by Comparative Transcriptomics.

Authors:  Ian Will; Biplabendu Das; Thienthanh Trinh; Andreas Brachmann; Robin A Ohm; Charissa de Bekker
Journal:  G3 (Bethesda)       Date:  2020-07-07       Impact factor: 3.154

3.  Tremorgenic effects and functional metabolomics analysis of lolitrem B and its biosynthetic intermediates.

Authors:  Priyanka Reddy; Simone Rochfort; Elizabeth Read; Myrna Deseo; Emily Jaehne; Maarten Van Den Buuse; Kathryn Guthridge; Martin Combs; German Spangenberg; Jane Quinn
Journal:  Sci Rep       Date:  2019-06-27       Impact factor: 4.379

4.  LINGO1 is a regulatory subunit of large conductance, Ca2+-activated potassium channels.

Authors:  Srikanth Dudem; Roddy J Large; Shruti Kulkarni; Heather McClafferty; Irina G Tikhonova; Gerard P Sergeant; Keith D Thornbury; Michael J Shipston; Brian A Perrino; Mark A Hollywood
Journal:  Proc Natl Acad Sci U S A       Date:  2020-01-13       Impact factor: 11.205

5.  Identification and Structure Elucidation of Epoxyjanthitrems from Lolium perenne Infected with the Endophytic Fungus Epichloë festucae var. lolii and Determination of the Tremorgenic and Anti-Insect Activity of Epoxyjanthitrem I.

Authors:  Sarah C Finch; Michèle R Prinsep; Alison J Popay; Alistair L Wilkins; Nicola G Webb; Sweta Bhattarai; Joanne G Jensen; Allan D Hawkes; Jacob V Babu; Brian A Tapper; Geoffrey A Lane
Journal:  Toxins (Basel)       Date:  2020-08-17       Impact factor: 4.546

Review 6.  Epichloë Fungal Endophytes-From a Biological Curiosity in Wild Grasses to an Essential Component of Resilient High Performing Ryegrass and Fescue Pastures.

Authors:  John R Caradus; Linda J Johnson
Journal:  J Fungi (Basel)       Date:  2020-11-27

7.  Toxic Indole Diterpenes from Endophyte-Infected Perennial Ryegrass Lolium perenne L.: Isolation and Stability.

Authors:  Priyanka Reddy; Myrna A Deseo; Vilnis Ezernieks; Kathryn Guthridge; German Spangenberg; Simone Rochfort
Journal:  Toxins (Basel)       Date:  2019-01-03       Impact factor: 4.546

8.  Identification and Distribution of Novel Metabolites of Lolitrem B in Mice by High-Resolution Mass Spectrometry.

Authors:  Priyanka Reddy; Aaron Elkins; Joanne Hemsworth; Kathryn Guthridge; Simone Vassiliadis; Elizabeth Read; German Spangenberg; Simone Rochfort
Journal:  Molecules       Date:  2020-01-16       Impact factor: 4.411
  8 in total

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