| Literature DB >> 3731922 |
A Eyraud, J Descotes, J Y Lombard, A Laschi-Loquerie, P Tachon, C Veysseyre, J C Evreux.
Abstract
The effects of three macrolide antibiotics were studied on rat polymorphonuclear leukocyte chemotaxis. Rats were given 25 mg/kg twice a day of either erythromycin, josamycin or spiramycin by gastric intubation for 5 days. In all cases, chemotaxis was found to be impaired by 10-20% only. As macrolides are known to reach high intracellular concentrations within polymorphonuclear leukocytes, our results suggest that these antibiotics are unlikely to exert a deleterious influence on the chemotactic response of treated patients.Entities:
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Year: 1986 PMID： 3731922 DOI： 10.1159/000238438
Source DB: PubMed Journal: Chemotherapy ISSN： 0009-3157 Impact factor: 2.544