Literature DB >> 10877454

Suppressive activity of a macrolide antibiotic, roxithromycin on co-stimulatory molecule expression on mouse splenocytes in vivo.

K Kawazu1, M Kurokawa, K Asano, A Mita, M Adachi.   

Abstract

The influence of roxithromycin (RXM) on the expression of co-stimulatory molecules, CD40, CD80 and CD86, was examined in vivo. When BALB/c mice were immunized intraperitoneally with two doses of dinitrophenylated ovalbumin (DNP-OVA) at 1 week intervals, intraperitoneal administration of RXM at 250 microg/kg once a day for 14 days strongly suppressed IgE contents in sera obtained from mice 22 days after the first immunization. In addition, RXM treatment of mice suppressed endogenous IL-4 contents in aqueous spleen extracts, which were enhanced by DNP-OVA immunization. We next examined the influence of RXM on co-stimulatory molecule expression on splenic lymphocytes. RXM treatment of the immunized mice caused suppression of CD40 expression, but this treatment did not affect CD80 and CD86 expression.

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Year:  2000        PMID： 10877454      PMCID： PMC1781739          DOI： 10.1080/09629350050024375

Source DB:  PubMed          Journal:  Mediators Inflamm        ISSN： 0962-9351            Impact factor:   4.711


  24 in total

1.  Hydrocortisone and IL-4 induce IgE isotype switching in human B cells.

Authors:  H H Jabara; D J Ahern; D Vercelli; R S Geha
Journal:  J Immunol       Date:  1991-09-01       Impact factor: 5.422

2.  The use of macrolide antibiotic substances in the treatment of asthma.

Authors:  I H Itkin; M L Menzel
Journal:  J Allergy       Date:  1970-03

3.  Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK-506 and rapamycin.

Authors:  F J Dumont; M J Staruch; S L Koprak; M R Melino; N H Sigal
Journal:  J Immunol       Date:  1990-01-01       Impact factor: 5.422

4.  Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma.

Authors:  Q Hamid; M Azzawi; S Ying; R Moqbel; A J Wardlaw; C J Corrigan; B Bradley; S R Durham; J V Collins; P K Jeffery
Journal:  J Clin Invest       Date:  1991-05       Impact factor: 14.808

5.  Both CD80 and CD86 co-stimulatory molecules regulate allergic pulmonary inflammation.

Authors:  D A Mark; C E Donovan; G T De Sanctis; S J Krinzman; L Kobzik; P S Linsley; M H Sayegh; J Lederer; D L Perkins; P W Finn
Journal:  Int Immunol       Date:  1998-11       Impact factor: 4.823

6.  Effects of erythromycin, josamycin and spiramycin on rat polymorphonuclear leukocyte chemotaxis.

Authors:  A Eyraud; J Descotes; J Y Lombard; A Laschi-Loquerie; P Tachon; C Veysseyre; J C Evreux
Journal:  Chemotherapy       Date:  1986       Impact factor: 2.544

Review 7.  The mechanism of action of cyclosporin A and FK506.

Authors:  S L Schreiber; G R Crabtree
Journal:  Immunol Today       Date:  1992-04

8.  Effect of antibiotics on the generation of reactive oxygen species.

Authors:  Y Miyachi; A Yoshioka; S Imamura; Y Niwa
Journal:  J Invest Dermatol       Date:  1986-04       Impact factor: 8.551

9.  Effect of antibiotics of chemotaxis of human leukocytes.

Authors:  A Forsgren; D Schmeling
Journal:  Antimicrob Agents Chemother       Date:  1977-04       Impact factor: 5.191

10.  Erythromycin reduces the severity of bronchial hyperresponsiveness in asthma.

Authors:  H Miyatake; F Taki; H Taniguchi; R Suzuki; K Takagi; T Satake
Journal:  Chest       Date:  1991-03       Impact factor: 9.410
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  3 in total

1.  Short-term roxithromycin treatment attenuates airway inflammation via MAPK/NF-κB activation in a mouse model of allergic asthma.

Authors:  Xinxin Ci; Xiao Chu; Xue Xu; Hongyu Li; Xuming Deng
Journal:  Inflamm Res       Date:  2012-04-06       Impact factor: 4.575

2.  Topical azithromycin and clarithromycin inhibit acute and chronic skin inflammation in sensitized mice, with apparent selectivity for Th2-mediated processes in delayed-type hypersensitivity.

Authors:  Vanesa Ivetić Tkalčević; Snježana Cužić; Miroslava Dominis Kramarić; Michael J Parnham; Vesna Eraković Haber
Journal:  Inflammation       Date:  2012-02       Impact factor: 4.092

3.  Inhibitory action of a macrolide antibiotic, roxithromycin, on co-stimulatory molecule expressions in vitro and in vivo.

Authors:  Mayumi Suzuki; Kazuhito Asano; Mei Yu; Tadashi Hisamitsu; Harumi Suzaki
Journal:  Mediators Inflamm       Date:  2002-08       Impact factor: 4.711
  3 in total

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