Literature DB >> 3729355

Pharmacokinetic study of lenampicillin (KBT-1585) in healthy volunteers.

A Saito, M Nakashima.   

Abstract

The pharmacokinetic properties of lenampicillin (KBT-1585), a new ampicillin ester, were investigated in 41 healthy volunteers. The maximum concentration of ampicillin in serum after oral administration of 400 mg of lenampicillin was 6.5 micrograms/ml at 0.70 h, and that after a equimolar dosage of ampicillin was 2.9 micrograms/ml at 0.87 h.

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Year:  1986        PMID： 3729355      PMCID： PMC284190          DOI： 10.1128/AAC.29.5.948

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  10 in total

1.  BRL.8988 (talampicillin), a well-absorbed oral form of ampicillin.

Authors:  J P Clayton; M Cole; S W Elson; H Ferres
Journal:  Antimicrob Agents Chemother       Date:  1974-06       Impact factor: 5.191

Review 2.  Influence of food and diet on gastrointestinal drug absorption: a review.

Authors:  P G Welling
Journal:  J Pharmacokinet Biopharm       Date:  1977-08

3.  Bioavailability of talampicillin.

Authors:  K H Jones
Journal:  Br Med J       Date:  1977-07-23

4.  [Studies on talampicillin. I. Absorption and excretion--comparison with ampicillin and effects of food intake].

Authors:  A Saito; Y Kato; K Murakami
Journal:  Kansenshogaku Zasshi       Date:  1975-07

5.  Influence of food and reduced gastric acidity on the bioavailability of bacampicillin and cefuroxime axetil.

Authors:  D K Sommers; M van Wyk; J Moncrieff; H S Schoeman
Journal:  Br J Clin Pharmacol       Date:  1984-10       Impact factor: 4.335

6.  Talampicillin: a new derivative of ampicillin.

Authors:  D A Leigh; D S Reeves; K Simmons; A L Thomas; P J Wilkinson
Journal:  Br Med J       Date:  1976-06-05

7.  Bacampicillin: a new orally well-absorbed derivative of ampicillin.

Authors:  N O Bodin; B Ekström; U Forsgren; L P Jalar; L Magni; C H Ramsay; B Sjöberg
Journal:  Antimicrob Agents Chemother       Date:  1975-11       Impact factor: 5.191

8.  Pharmacokinetics of bacampicillin compared with those of ampicillin, pivampicillin, and amoxycillin.

Authors:  J Sjövall; L Magni; T Bergan
Journal:  Antimicrob Agents Chemother       Date:  1978-01       Impact factor: 5.191

9.  Bioavailability and metabolism of talampicillin.

Authors:  K H Jones; P F Langley; L J Lees
Journal:  Chemotherapy       Date:  1978       Impact factor: 2.544

Review 10.  The pharmacokinetics of bacampicillin.

Authors:  H C Neu
Journal:  Rev Infect Dis       Date:  1981 Jan-Feb
  10 in total
  1 in total

1.  Human carboxymethylenebutenolidase as a bioactivating hydrolase of olmesartan medoxomil in liver and intestine.

Authors:  Tomoko Ishizuka; Izumi Fujimori; Mitsunori Kato; Chisa Noji-Sakikawa; Motoko Saito; Yasushi Yoshigae; Kazuishi Kubota; Atsushi Kurihara; Takashi Izumi; Toshihiko Ikeda; Osamu Okazaki
Journal:  J Biol Chem       Date:  2010-02-19       Impact factor: 5.157
  1 in total

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