Literature DB >> 3724969

Pertussis vaccine reduces agonist binding to the rat heart muscarinic receptor and its guanine nucleotide modulation.

J S Aguilar, M I Fonseca, E De Robertis.   

Abstract

The injection of Bordetella pertussis, inactivated by merthiolate, causes a 2-fold increase in the IC50 of carbamylcholine (carbachol) in displacing [3H];-L(-) quinuclidinyl benzilate binding ([3H]QNB) to the receptor. In control animals, 50 microM Gpp(NH)p causes a 6-fold decrease in the affinity of carbachol binding, whereas after vaccination the reduction is only 1.6-fold. After pertussis treatment there is no alteration in the affinity and number of [3H]QNB binding sites of to the muscarinic receptor.

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Year:  1986        PMID： 3724969     DOI： 10.1007/bf00965342

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  26 in total

1.  The regulation of muscarinic cholinergic receptors by guanine nucleotides in cardiac tissue.

Authors:  L B Rosenberger; W R Roeske; H I Yamamura
Journal:  Eur J Pharmacol       Date:  1979-06       Impact factor: 4.432

2.  Direct action of pertussis toxin in isolated hamster fat cells.

Authors:  M A Martínez-Olmedo; J A García-Sáinz
Journal:  Eur J Pharmacol       Date:  1984-03-16       Impact factor: 4.432

3.  Differences and similarities in muscarinic receptors of rat heart and retina: effects of agonists, guanine nucleotides, and N-ethylmaleimide.

Authors:  J Dunlap; J H Brown
Journal:  J Neurochem       Date:  1984-07       Impact factor: 5.372

4.  ADP-ribosylation of Gs promotes the dissociation of its alpha and beta subunits.

Authors:  R A Kahn; A G Gilman
Journal:  J Biol Chem       Date:  1984-05-25       Impact factor: 5.157

5.  Attenuation of chick heart adenylate cyclase by muscarinic receptors after pertussis toxin treatment.

Authors:  K K McMahon; R D Green; M M Hosey
Journal:  Biochem Biophys Res Commun       Date:  1985-01-16       Impact factor: 3.575

6.  Agonist-antagonist interactions with rat atrial muscarinic cholinergic receptor sites: differential regulation by guanine nucleotides.

Authors:  J W Wei; P V Sulakhe
Journal:  Eur J Pharmacol       Date:  1979-09-01       Impact factor: 4.432

7.  Subunit structure of islet-activating protein, pertussis toxin, in conformity with the A-B model.

Authors:  M Tamura; K Nogimori; S Murai; M Yajima; K Ito; T Katada; M Ui; S Ishii
Journal:  Biochemistry       Date:  1982-10-26       Impact factor: 3.162

8.  Modification by islet-activating protein of receptor-mediated regulation of cyclic AMP accumulation in isolated rat heart cells.

Authors:  O Hazeki; M Ui
Journal:  J Biol Chem       Date:  1981-03-25       Impact factor: 5.157

9.  Regulation of ligand binding to cardiac muscarinic receptors by ammonium ion and guanine nucleotides.

Authors:  M M Hosey
Journal:  Biochim Biophys Acta       Date:  1983-05-04

10.  Specific uncoupling by islet-activating protein, pertussis toxin, of negative signal transduction via alpha-adrenergic, cholinergic, and opiate receptors in neuroblastoma x glioma hybrid cells.

Authors:  H Kurose; T Katada; T Amano; M Ui
Journal:  J Biol Chem       Date:  1983-04-25       Impact factor: 5.157
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