Literature DB >> 3724956

Quantitative histochemistry of brain acetylcholinesterase and learning rate in the aged rat.

A Biegon, V Greenberger, M Segal.   

Abstract

Using a newly developed method for quantitative acetylcholinesterase (AChE) histochemistry we find a substantial decrease in AChE content in aged rats compared to young controls in the cholinergic cell body regions (the ventral pallidum and the medial septal nuclei) and, to a smaller extent in the projection areas (the cortex and hippocampus). In the same group of aged rats we find a severe deficit in the acquisition of a water maze task. Quantitative histochemistry is a potent method for detecting localized changes in AChE content in otherwise intact, learning-impaired aged rats.

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Year:  1986        PMID： 3724956     DOI： 10.1016/0197-4580(86)90046-1

Source DB:  PubMed          Journal:  Neurobiol Aging        ISSN： 0197-4580            Impact factor:   4.673


  11 in total

1.  Long-term functional recovery from age-induced spatial memory impairments by nerve growth factor gene transfer to the rat basal forebrain.

Authors:  A Martínez-Serrano; W Fischer; S Söderström; T Ebendal; A Björklund
Journal:  Proc Natl Acad Sci U S A       Date:  1996-06-25       Impact factor: 11.205

Review 2.  Behavioral screening for cognition enhancers: from indiscriminate to valid testing: Part I.

Authors:  M Sarter; J Hagan; P Dudchenko
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530

3.  Altered levels of amyloid protein precursor transcripts in the basal forebrain of behaviorally impaired aged rats.

Authors:  G A Higgins; G A Oyler; R L Neve; K S Chen; F H Gage
Journal:  Proc Natl Acad Sci U S A       Date:  1990-04       Impact factor: 11.205

4.  Muscarinic receptors mediating depression and long-term potentiation in rat hippocampus.

Authors:  J M Auerbach; M Segal
Journal:  J Physiol       Date:  1996-04-15       Impact factor: 5.182

Review 5.  Positron emission tomography studies of organophosphate chemical threats and oxime countermeasures.

Authors:  Charles M Thompson; John M Gerdes; Henry F VanBrocklin
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6.  Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats.

Authors:  A Zanotti; L Valzelli; G Toffano
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530

7.  From eyes-closed to eyes-open: Role of cholinergic projections in EC-to-EO alpha reactivity revealed by combining EEG and MRI.

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Journal:  Hum Brain Mapp       Date:  2018-09-25       Impact factor: 5.038

Review 8.  Astroglia in Alzheimer's Disease.

Authors:  Alexei Verkhratsky; Vladimir Parpura; Jose Julio Rodriguez-Arellano; Robert Zorec
Journal:  Adv Exp Med Biol       Date:  2019       Impact factor: 2.622

9.  Comparative study of the effects of tianeptine and other antidepressants on the activity of medial septal neurons in rats anesthetized with urethane.

Authors:  M H Bassant; B H Lee; F Jazat; Y Lamour
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1991-11       Impact factor: 3.000

10.  Transplanted bone marrow mesenchymal stem cells improve memory in rat models of Alzheimer's disease.

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Journal:  Stem Cells Int       Date:  2012-06-14       Impact factor: 5.443
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