Literature DB >> 2920741

beta-Methyl-15-p-iodophenylpentadecanoic acid metabolism and kinetics in the isolated rat heart.

T R DeGrado1, J E Holden, C K Ng, D M Raffel, S J Gatley.   

Abstract

The use of 15-p-iodophenyl-beta-methyl-pentadecanoic acid (beta Me-IPPA) as an indicator of long chain fatty acid (LCFA) utilization in nuclear medicine studies was evaluated in the isolated, perfused, working rat heart. Time courses of radioactivity (residue curves) were obtained following bolus injections of both beta Me-IPPA and its straight chain counterpart 15-p-iodophenyl-pentadecanoic acid (IPPA). IPPA kinetics clearly indicated flow independent impairment of fatty acid oxidation caused by the carnitine palmitoyltransferase I inhibitor 2[5(4-chlorophenyl)pentyl]oxirane-2-carboxylate (POCA). In contrast, beta Me-IPPA kinetics were insensitive to changes in fatty acid oxidation rate and net utilization of long chain fatty acid. Analysis of radiolabeled species in coronary effluent and heart homogenates showed the methylated fatty acid to be readily incorporated into complex lipids but a poor substrate for oxidation. POCA did not significantly alter metabolism of the tracer, suggesting that the tracer is poorly metabolized beyond beta Me-IPPA-CoA in the oxidative pathway.

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Year:  1989        PMID： 2920741     DOI： 10.1007/BF00702623

Source DB:  PubMed          Journal:  Eur J Nucl Med        ISSN： 0340-6997


  13 in total

1.  Efflux of metabolized and nonmetabolized fatty acid from canine myocardium. Implications for quantifying myocardial metabolism tomographically.

Authors:  K A Fox; D R Abendschein; H D Ambos; B E Sobel; S R Bergmann
Journal:  Circ Res       Date:  1985-08       Impact factor: 17.367

2.  Effect of glucose and insulin infusion on the myocardial extraction of a radioiodinated methyl-substituted fatty acid.

Authors:  J A Bianco; D R Elmaleh; J A Leppo; M A King; A Moring; E Livni; E Espinoza; J S Alpert; H W Strauss
Journal:  Eur J Nucl Med       Date:  1986

3.  Comparison of 16-iodohexadecanoic acid (IHDA) and 15-p-iodophenylpentadecanoic acid (IPPA) metabolism and kinetics in the isolated rat heart.

Authors:  T R DeGrado; J E Holden; C K Ng; D M Raffel; S J Gatley
Journal:  Eur J Nucl Med       Date:  1988

4.  Beta-methyl[1-11C]heptadecanoic acid: a new myocardial metabolic tracer for positron emission tomography.

Authors:  E Livni; D R Elmaleh; S Levy; G L Brownell; W H Strauss
Journal:  J Nucl Med       Date:  1982-02       Impact factor: 10.057

5.  Measurement of myocardial fatty acid metabolism: kinetics of iodine-123 heptadecanoic acid in normal dog hearts.

Authors:  H R Schön; R Senekowitsch; D Berg; M Schneidereit; G Reidel; H Kriegel; H W Pabst; H Blömer
Journal:  J Nucl Med       Date:  1986-09       Impact factor: 10.057

6.  Radioiodinated branched-chain fatty acids: substrates for beta oxidation? Concise communication.

Authors:  C A Otto; L E Brown; A M Scott
Journal:  J Nucl Med       Date:  1984-01       Impact factor: 10.057

7.  Kinetics of iodomethylated hexadecanoic acid metabolism in the rat myocardium: influence of the number and the position of methyl radicals.

Authors:  D Fagret; L Bontemps; M Apparu; C Keriel; J P Mathieu; C Pernin; M Vidal; M Comet; P Cuchet
Journal:  Int J Nucl Med Biol       Date:  1985

8.  Effect of 3-methyl-branching on the metabolism in rat hearts of radioiodinated iodovinyl long chain fatty acids.

Authors:  K R Ambrose; D E Rice; M M Goodman; F F Knapp
Journal:  Eur J Nucl Med       Date:  1987

9.  Metabolic fate of radiolabeled palmitate in ischemic canine myocardium: implications for positron emission tomography.

Authors:  T L Rosamond; D R Abendschein; B E Sobel; S R Bergmann; K A Fox
Journal:  J Nucl Med       Date:  1987-08       Impact factor: 10.057

10.  Dual tracer autoradiographic study of beta-methyl-(1-14C) heptadecanoic acid and 15-p-(131I)-iodophenyl-beta-methylpentadecanoic acid in normotensive and hypertensive rats.

Authors:  K Yamamoto; P Som; A B Brill; Y Yonekura; S C Srivastava; G E Meinken; J Iwai; M M Goodman; F F Knapp; D R Elmaleh
Journal:  J Nucl Med       Date:  1986-07       Impact factor: 10.057
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  8 in total

1.  Catabolism of 15-(p-iodophenyl)-R,S-beta-methylpentadecanoic acid (BMIPP) by isolated rat hearts.

Authors:  T R DeGrado; J E Holden; S J Gatley
Journal:  Eur J Nucl Med       Date:  1990

2.  Catabolism of 15-(p-iodophenyl)-3-R,S-methylpentadecanoic acid (BMIPP) by isolated rat hearts.

Authors:  F F Knapp; K R Ambrose; R Dudczak; S N Reske; J Kropp
Journal:  Eur J Nucl Med       Date:  1990

Review 3.  Imaging of myocardial fatty acid oxidation.

Authors:  Kieren J Mather; Timothy R DeGrado
Journal:  Biochim Biophys Acta       Date:  2016-02-27

4.  Recovery of impaired left ventricular function in patients with acute myocardial infarction is predicted by the discordance in defect size on 123I-BMIPP and 201Tl SPET images.

Authors:  T Ito; J Tanouchi; J Kato; T Morioka; M Nishino; K Iwai; H Tanahashi; Y Yamada; M Hori; T Kamada
Journal:  Eur J Nucl Med       Date:  1996-08

5.  Combined study with I-123 fatty acid and thallium-201 to assess ischemic myocardium: comparison with thallium redistribution and glucose metabolism.

Authors:  M Kawamoto; N Tamaki; Y Yonekura; E Tadamura; Y Fujibayashi; Y Magata; R Nohara; S Sasayama; K Ikekubo; H Kato
Journal:  Ann Nucl Med       Date:  1994-02       Impact factor: 2.668

6.  Structure dependence of long-chain [18F]fluorothia fatty acids as myocardial fatty acid oxidation probes.

Authors:  Mukesh K Pandey; Anthony P Belanger; Shuyan Wang; Timothy R DeGrado
Journal:  J Med Chem       Date:  2012-11-27       Impact factor: 7.446

7.  Evaluation of cellular viability by quantitative autoradiographic study of myocardial uptake of a fatty acid analogue in isoproterenol-induced focal rat heart necrosis.

Authors:  T Humbert; C Luu-Duc; M Comet; P Demenge
Journal:  Eur J Nucl Med       Date:  1991

8.  Kinetics of radioiodinated species in subcellular fractions from rat hearts following administration of iodine-123-labelled 15-(p-iodophenyl)-3-(R,S)-methylpentadecanoic acid (123I-BMIPP).

Authors:  S Morishita; H Kusuoka; Y Yamamichi; N Suzuki; M Kurami; T Nishimura
Journal:  Eur J Nucl Med       Date:  1996-04
  8 in total

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