Literature DB >> 3718519

Cell-free synthesis of delta-(L-alpha-aminoadipyl)-L-cysteine, the first intermediate of penicillin and cephalosporin biosynthesis.

G Banko, S Wolfe, A L Demain.   

Abstract

delta-(L-alpha-aminoadipyl)-L-cysteine synthetase (LL-AC synthetase) activity has been found in extracts of Cephalosporium acremonium C-10. The enzyme extract carries out a linear synthesis of LL-AC from its constituent amino acids for at least 6 hours. The reaction is dependent on active enzyme, time, L-alpha-aminoadipate, L-cysteine, ATP and Mn2+ or Mg2+. The activity is stabilized by glycerol.

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Year:  1986        PMID： 3718519     DOI： 10.1016/0006-291x(86)91242-8

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  12 in total

1.  Purification and partial characterization of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase from Streptomyces clavuligerus.

Authors:  S E Jensen; A Wong; M J Rollins; D W Westlake
Journal:  J Bacteriol       Date:  1990-12       Impact factor: 3.490

2.  Biochemical studies on the activity of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase from Streptomyces clavuligerus.

Authors:  J Zhang; S Wolfe; A L Demain
Journal:  Biochem J       Date:  1992-05-01       Impact factor: 3.857

3.  The cefG gene of Cephalosporium acremonium is linked to the cefEF gene and encodes a deacetylcephalosporin C acetyltransferase closely related to homoserine O-acetyltransferase.

Authors:  S Gutiérrez; J Velasco; F J Fernandez; J F Martín
Journal:  J Bacteriol       Date:  1992-05       Impact factor: 3.490

Review 4.  δ-(L-α-aminoadipyl)-L-cysteinyl-D-valine synthetase (ACVS): discovery and perspectives.

Authors:  Kapil Tahlan; Marcus A Moore; Susan E Jensen
Journal:  J Ind Microbiol Biotechnol       Date:  2016-10-20       Impact factor: 3.346

5.  Characterization of the Cephalosporium acremonium pcbAB gene encoding alpha-aminoadipyl-cysteinyl-valine synthetase, a large multidomain peptide synthetase: linkage to the pcbC gene as a cluster of early cephalosporin biosynthetic genes and evidence of multiple functional domains.

Authors:  S Gutiérrez; B Díez; E Montenegro; J F Martín
Journal:  J Bacteriol       Date:  1991-04       Impact factor: 3.490

Review 6.  Molecular regulation of beta-lactam biosynthesis in filamentous fungi.

Authors:  A A Brakhage
Journal:  Microbiol Mol Biol Rev       Date:  1998-09       Impact factor: 11.056

7.  Low-molecular-weight thiols in streptomycetes and their potential role as antioxidants.

Authors:  G L Newton; R C Fahey; G Cohen; Y Aharonowitz
Journal:  J Bacteriol       Date:  1993-05       Impact factor: 3.490

8.  Production of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine by entrapped ACV-synthetase from Streptomyces clavuligerus.

Authors:  T A Kadima; S E Jensen; M A Pickard
Journal:  J Ind Microbiol       Date:  1995-01

9.  Production kinetics and stability properties of delta(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase from Streptomyces clavuligerus.

Authors:  T A Kadima; S E Jensen; M A Pickard
Journal:  J Ind Microbiol       Date:  1993-01

Review 10.  Clusters of genes for the biosynthesis of antibiotics: regulatory genes and overproduction of pharmaceuticals.

Authors:  J F Martin
Journal:  J Ind Microbiol       Date:  1992 Feb-Mar
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