Literature DB >> 3718482

Binding of heparin to human platelet factor 4.

S W Cowan, E N Bakshi, K J Machin, N W Isaacs.   

Abstract

Platelet factor 4 is a small protein (Mr 7756) from the alpha-granules of blood platelets which binds strongly to and neutralizes the anticoagulant properties of heparin. From an analysis of X-ray crystallographic data a model for the binding of platelet factor 4 to heparin is proposed.

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Year:  1986        PMID： 3718482      PMCID： PMC1146592          DOI： 10.1042/bj2340485

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  19 in total

1.  Platelet antiheparin proteins and antithrombin III interact with different binding sites on heparin molecule.

Authors:  S Niewiarowski; B Rucinski; P James; U Lindahl
Journal:  FEBS Lett       Date:  1979-06-01       Impact factor: 4.124

2.  Solvent content of protein crystals.

Authors:  B W Matthews
Journal:  J Mol Biol       Date:  1968-04-28       Impact factor: 5.469

3.  Prediction of the secondary structure of platelet factor 4 and beta-thromboglobulin from their amino acid sequences.

Authors:  J W Lawler
Journal:  Thromb Res       Date:  1981 Jan 1-15       Impact factor: 3.944

4.  The molecular size of the antithrombin-binding sequence in heparin.

Authors:  L Thunberg; G Bäckström; H Grundberg; J Riesenfeld; U Lindahl
Journal:  FEBS Lett       Date:  1980-08-11       Impact factor: 4.124

5.  The molecular-weight-dependence of the anti-coagulant activity of heparin.

Authors:  T C Laurent; A Tengblad; L Thunberg; M Höök; U Lindahl
Journal:  Biochem J       Date:  1978-11-01       Impact factor: 3.857

6.  Purification and binding properties of human platelet factor four.

Authors:  R I Handin; H J Cohen
Journal:  J Biol Chem       Date:  1976-07-25       Impact factor: 5.157

7.  X-ray diffraction analysis of crystals of bovine platelet factor 4.

Authors:  R St Charles; R E Ciaglowski; D Walz; B F Edwards
Journal:  J Mol Biol       Date:  1984-07-05       Impact factor: 5.469

8.  Dansyl (5-dimethylaminonaphthalene-1-sulphonyl)-heparin binds antithrombin III and platelet factor 4 at separate sites.

Authors:  M W Piepkorn
Journal:  Biochem J       Date:  1981-05-15       Impact factor: 3.857

9.  Evidence for a 3-O-sulfated D-glucosamine residue in the antithrombin-binding sequence of heparin.

Authors:  U Lindahl; G Bäckström; L Thunberg; I G Leder
Journal:  Proc Natl Acad Sci U S A       Date:  1980-11       Impact factor: 11.205

10.  Studies on the chemistry of human platelet factor 4.

Authors:  F J Morgan; C N Chesterman; J R McGready; G S Begg
Journal:  Haemostasis       Date:  1977
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  6 in total

1.  Platelet Factor 4 Interactions with Short Heparin Oligomers: Implications for Folding and Assembly.

Authors:  Chendi Niu; Yang Yang; Angela Huynh; Ishac Nazy; Igor A Kaltashov
Journal:  Biophys J       Date:  2020-04-21       Impact factor: 4.033

2.  Secondary structure of neutrophil-activating peptide-2 determined by 1H-nuclear magnetic resonance spectroscopy.

Authors:  K H Mayo; Y Yang; T J Daly; J K Barry; G J La Rosa
Journal:  Biochem J       Date:  1994-12-01       Impact factor: 3.857

Review 3.  Atomic features of an autoantigen in heparin-induced thrombocytopenia (HIT).

Authors:  Zheng Cai; Zhiqiang Zhu; Mark I Greene; Douglas B Cines
Journal:  Autoimmun Rev       Date:  2016-03-09       Impact factor: 9.754

4.  N.m.r. and molecular-modelling studies of the solution conformation of heparin.

Authors:  B Mulloy; M J Forster; C Jones; D B Davies
Journal:  Biochem J       Date:  1993-08-01       Impact factor: 3.857

5.  Heparin binding to platelet factor-4. An NMR and site-directed mutagenesis study: arginine residues are crucial for binding.

Authors:  K H Mayo; E Ilyina; V Roongta; M Dundas; J Joseph; C K Lai; T Maione; T J Daly
Journal:  Biochem J       Date:  1995-12-01       Impact factor: 3.857

6.  Atomic description of the immune complex involved in heparin-induced thrombocytopenia.

Authors:  Zheng Cai; Serge V Yarovoi; Zhiqiang Zhu; Lubica Rauova; Vincent Hayes; Tatiana Lebedeva; Qun Liu; Mortimer Poncz; Gowthami Arepally; Douglas B Cines; Mark I Greene
Journal:  Nat Commun       Date:  2015-09-22       Impact factor: 14.919
  6 in total

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