Literature DB >> 3718233

Different pharmacokinetics of dichlorofluoromethane (CFC 21) and chlorodifluoromethane (CFC 22).

H Peter, J G Filser, L von Szentpály, H J Wiegand.   

Abstract

Inhalation pharmacokinetics of dichlorofluoromethane (CFC 21) and chlorodifluoromethane (CFC 22) were studied in male Wistar rats by use of a closed inhalation chamber system. CFC 21 was readily eliminated via metabolism. However, CFC 22 underwent no detectable metabolism; pretreatment of the rats with DDT or phenobarbital did not stimulate metabolic transformation of the compound. Hence, formation of biologically relevant amounts of reactive intermediates from CFC 22 as a mechanism of toxicity seems unlikely.

Entities:  

Mesh：

Substances：

Year:  1986        PMID： 3718233     DOI： 10.1007/bf00297122

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  6 in total

1.  [Studies on inhalation toxicity of fluorine derivatives of methane, ethane and cyclobutane].

Authors:  W Weigand
Journal:  Zentralbl Arbeitsmed       Date:  1971-05

2.  The toxicological evaluation of chlorofluorocarbon 22 (CFC 22).

Authors:  M H Litchfield; E Longstaff
Journal:  Food Chem Toxicol       Date:  1984-06       Impact factor: 6.023

3.  Pharmacokinetics of halogenated ethylenes in rats.

Authors:  J G Filser; H M Bolt
Journal:  Arch Toxicol       Date:  1979-06-08       Impact factor: 5.153

4.  Inhalation pharmacokinetics based on gas uptake studies. I. Improvement of kinetic models.

Authors:  J G Filser; H M Bolt
Journal:  Arch Toxicol       Date:  1981-07       Impact factor: 5.153

5.  DNA-binding assay of methyl chloride.

Authors:  H Peter; R J Laib; H Ottenwälder; H Topp; N Rupprich; H M Bolt
Journal:  Arch Toxicol       Date:  1985-06       Impact factor: 5.153

6.  Inhalation pharmacokinetics based on gas uptake studies. V. Comparative pharmacokinetics of ethylene and 1,3-butadiene in rats.

Authors:  H M Bolt; J G Filser; F Störmer
Journal:  Arch Toxicol       Date:  1984-10       Impact factor: 5.153
  6 in total
  3 in total

Review 1.  The closed chamber technique--uptake, endogenous production, excretion, steady-state kinetics and rates of metabolism of gases and vapors.

Authors:  J G Filser
Journal:  Arch Toxicol       Date:  1992       Impact factor: 5.153

2.  Human inhalation pharmacokinetics of chlorodifluoromethane (HCFC22).

Authors:  B H Woollen; J R Marsh; J D Mahler; T R Auton; D Makepeace; J Cocker; P G Blain
Journal:  Int Arch Occup Environ Health       Date:  1992       Impact factor: 3.015

Review 3.  Metabolism and toxicity of hydrochlorofluorocarbons: current knowledge and needs for the future.

Authors:  M W Anders
Journal:  Environ Health Perspect       Date:  1991-12       Impact factor: 9.031
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.