Literature DB >> 3716836

In vitro intestinal transport of vasopressin and its analogues.

H Vilhardt, S Lundin.   

Abstract

The intestinal transport of vasopressin and oxytocin and their analogues 1-deamino-8-D-arginine vasopressin and 1-deamino-2-tyrosine(omicron-ethyl)-oxytocin was studied in everted segments of rat jejunum. The transported peptides were identified by specific RIA methods and by quantitative high pressure liquid chromatography. Transport rates were highest for 1-deamino-8-D-arginine vasopressin and lowest for vasopressin. No transport maximum and no competitive inhibition could be demonstrated. The distribution volume of the peptides in the intestinal mucosa was found to be smaller than that of polyethylene glycol. It is concluded that peptides of this size are transferred across the intestinal mucosa by passive processes.

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Year:  1986        PMID： 3716836     DOI： 10.1111/j.1748-1716.1986.tb07861.x

Source DB:  PubMed          Journal:  Acta Physiol Scand        ISSN： 0001-6772


  8 in total

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4.  Differences in transport rate of oxytocin and vasopressin analogues across proximal and distal isolated segments of the small intestine of the rat.

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5.  Absolute bioavailability of an aqueous solution of 1-deamino-8-D-arginine vasopressin from different regions of the gastrointestinal tract in man.

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7.  Intestinal transepithelial permeability of oxytocin into the blood is dependent on the receptor for advanced glycation end products in mice.

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Review 8.  Impact of non-proteinogenic amino acids in the discovery and development of peptide therapeutics.

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