Literature DB >> 3710909

Novel antibiotics napyradiomycins. Production, isolation, physico-chemical properties and biological activity.

K Shiomi, H Iinuma, M Hamada, H Naganawa, M Manabe, C Matsuki, T Takeuchi, H Umezawa.   

Abstract

Novel antibacterial antibiotics napyradiomycins A, B1, B2, B3, C1 and C2 have been isolated from the culture broth of Chainia rubra MG802-AF1. In this paper, taxonomy of the producer, and production, isolation, physico-chemical properties and biological activities of napyradiomycins are reported. They contain the naphtopyran chromophore and halogens, and inhibit the growth of Gram-positive bacteria including drug-resistant strains.

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Year:  1986        PMID: 3710909     DOI: 10.7164/antibiotics.39.487

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN: 0021-8820            Impact factor:   2.649


  15 in total

1.  Phylogenetic and chemical diversity of a hybrid-isoprenoid-producing streptomycete lineage.

Authors:  Kelley A Gallagher; Kristin Rauscher; Laura Pavan Ioca; Paul R Jensen
Journal:  Appl Environ Microbiol       Date:  2013-08-30       Impact factor: 4.792

2.  Meroterpenoid natural products from Streptomyces bacteria - the evolution of chemoenzymatic syntheses.

Authors:  Lauren A M Murray; Shaun M K McKinnie; Bradley S Moore; Jonathan H George
Journal:  Nat Prod Rep       Date:  2020-06-30       Impact factor: 13.423

3.  Bioactive compounds from marine actinomycetes.

Authors:  Renu Solanki; Monisha Khanna; Rup Lal
Journal:  Indian J Microbiol       Date:  2009-01-08       Impact factor: 2.461

4.  A unifying paradigm for naphthoquinone-based meroterpenoid (bio)synthesis.

Authors:  Zachary D Miles; Stefan Diethelm; Henry P Pepper; David M Huang; Jonathan H George; Bradley S Moore
Journal:  Nat Chem       Date:  2017-07-31       Impact factor: 24.427

5.  Total Enzyme Syntheses of Napyradiomycins A1 and B1.

Authors:  Shaun M K McKinnie; Zachary D Miles; Peter A Jordan; Takayoshi Awakawa; Henry P Pepper; Lauren A M Murray; Jonathan H George; Bradley S Moore
Journal:  J Am Chem Soc       Date:  2018-12-14       Impact factor: 15.419

6.  Napyradiomycin derivatives, produced by a marine-derived actinomycete, illustrate cytotoxicity by induction of apoptosis.

Authors:  Lauge Farnaes; Nicole G Coufal; Christopher A Kauffman; Arnold L Rheingold; Antonio G DiPasquale; Paul R Jensen; William Fenical
Journal:  J Nat Prod       Date:  2013-12-13       Impact factor: 4.050

7.  Enantioselective Synthesis of Azamerone.

Authors:  Matthew L Landry; Grace M McKenna; Noah Z Burns
Journal:  J Am Chem Soc       Date:  2019-02-08       Impact factor: 15.419

8.  Napyradiomycins CNQ525.510B and A80915C target the Hsp90 paralogue Grp94.

Authors:  Lauge Farnaes; James J La Clair; William Fenical
Journal:  Org Biomol Chem       Date:  2013-11-29       Impact factor: 3.876

9.  Characterization and Biochemical Assays of Streptomyces Vanadium-Dependent Chloroperoxidases.

Authors:  Shaun M K McKinnie; Zachary D Miles; Bradley S Moore
Journal:  Methods Enzymol       Date:  2018-04-02       Impact factor: 1.600

10.  Cytotoxic and Antimicrobial Napyradiomycins from Two Marine-Derived, MAR 4 Streptomyces Strains.

Authors:  Yuan-Bin Cheng; Paul R Jensen; William Fenical
Journal:  European J Org Chem       Date:  2013-06-01
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