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Literature DB >> 3707542

The effect of HhaI methylation on DNA local structure.

Abstract

The effect of methylating the central cytosine in the sequence GCGC on the sensitivity to digestion by deoxyribonuclease I was investigated. Examination of five such sites shows that the extra methyl group renders the bond on its 5' side more susceptible to cleavage, and this is interpreted by suggesting that it causes small changes in the local DNA phosphate orientation.

Entities: Chemical

Mesh：

Substances：

Year: 1986 PMID： 3707542 PMCID： PMC1146547 DOI： 10.1042/bj2340213

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

18 in total

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5 in total

1. Binding of the transcription factor EBP-80 mediates the methylation response of an intracisternal A-particle long terminal repeat promoter.

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Journal: Mol Cell Biol Date: 1991-01 Impact factor: 4.272

2. Cytosine methylation in CTF and Sp1 recognition sites of an HSV tk promoter: effects on transcription in vivo and on factor binding in vitro.

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3. Probing DNA shape and methylation state on a genomic scale with DNase I.

Authors: Allan Lazarovici; Tianyin Zhou; Anthony Shafer; Ana Carolina Dantas Machado; Todd R Riley; Richard Sandstrom; Peter J Sabo; Yan Lu; Remo Rohs; John A Stamatoyannopoulos; Harmen J Bussemaker
Journal: Proc Natl Acad Sci U S A Date: 2013-04-01 Impact factor: 11.205

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5 in total