| Literature DB >> 3704431 |
T S Kilduff, S S Bowersox, K I Kaitin, T L Baker, R D Ciaranello, W C Dement.
Abstract
The role of the muscarinic cholinergic receptor in narcolepsy was examined using radioligand binding to various brain regions of normal and genetically narcoleptic Doberman pinschers. In this multi-litter study, a previous report of a proliferation of muscarinic cholinergic receptors in the brainstem was confirmed, and the concentration of the M2 receptor subtype, in particular, was elevated. This up-regulation of brainstem cholinergic receptors suggests a problem with release of acetylcholine, which, together with previous reports of an impairment of dopamine release, may be indicative of a fundamental membrane problem in narcolepsy.Entities:
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Year: 1986 PMID： 3704431 DOI： 10.1093/sleep/9.1.102
Source DB: PubMed Journal: Sleep ISSN： 0161-8105 Impact factor: 5.849