Literature DB >> 3700411

Control of gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Multiple dioxin-responsive domains 5'-ward of the cytochrome P1-450 gene.

P B Jones, L K Durrin, J M Fisher, J P Whitlock.   

Abstract

In mouse hepatoma cells, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) stimulates cytochrome P1-450 gene transcription via the formation of TCDD-receptor complexes and the accumulation of the complexes in the nucleus. Here, we show that the DNA that flanks the 5'-end of the cytochrome P1-450 gene contains at least two discrete TCDD-responsive domains. Each domain has properties analogous to those of transcriptional enhancers. Each domain requires TCDD-receptor complexes for its function. There is no significant nucleotide sequence homology between the two TCDD-responsive domains.

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Year:  1986        PMID： 3700411

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  14 in total

1.  Glutathione S-transferase Ya subunit gene: identification of regulatory elements required for basal level and inducible expression.

Authors:  C A Telakowski-Hopkins; R G King; C B Pickett
Journal:  Proc Natl Acad Sci U S A       Date:  1988-02       Impact factor: 11.205

2.  Multiple DNA-binding factors interact with overlapping specificities at the aryl hydrocarbon response element of the cytochrome P450IA1 gene.

Authors:  F Saatcioglu; D J Perry; D S Pasco; J B Fagan
Journal:  Mol Cell Biol       Date:  1990-12       Impact factor: 4.272

3.  In situ protein-DNA interactions at a dioxin-responsive enhancer associated with the cytochrome P1-450 gene.

Authors:  L K Durrin; J P Whitlock
Journal:  Mol Cell Biol       Date:  1987-08       Impact factor: 4.272

4.  Aryl hydrocarbon induction of rat cytochrome P-450d results from increased precursor RNA processing.

Authors:  G Silver; K S Krauter
Journal:  Mol Cell Biol       Date:  1990-12       Impact factor: 4.272

5.  The Ah domain of the mouse. Induction of proteins by the carcinogen 3-methylcholanthrene.

Authors:  G Silver; K S Krauter
Journal:  Biochem J       Date:  1988-05-15       Impact factor: 3.857

6.  Aryl hydrocarbon-induced interactions at multiple DNA elements of diverse sequence--a multicomponent mechanism for activation of cytochrome P4501A1 (CYP1A1) gene transcription.

Authors:  R W Robertson; L Zhang; D S Pasco; J B Fagan
Journal:  Nucleic Acids Res       Date:  1994-05-11       Impact factor: 16.971

7.  Regulation of cytochrome P-450b/e gene expression by a heme- and phenobarbitone-modulated transcription factor.

Authors:  P N Rangarajan; G Padmanaban
Journal:  Proc Natl Acad Sci U S A       Date:  1989-06       Impact factor: 11.205

8.  Induction of the Cyp1a-1 dioxin-responsive enhancer in transgenic mice.

Authors:  S N Jones; P G Jones; H Ibarguen; C T Caskey; W J Craigen
Journal:  Nucleic Acids Res       Date:  1991-12-11       Impact factor: 16.971

9.  Characterization of xenobiotic responsive elements upstream from the drug-metabolizing cytochrome P-450c gene: a similarity to glucocorticoid regulatory elements.

Authors:  A Fujisawa-Sehara; K Sogawa; M Yamane; Y Fujii-Kuriyama
Journal:  Nucleic Acids Res       Date:  1987-05-26       Impact factor: 16.971

Review 10.  The aryl hydrocarbon receptor complex and the control of gene expression.

Authors:  Timothy V Beischlag; J Luis Morales; Brett D Hollingshead; Gary H Perdew
Journal:  Crit Rev Eukaryot Gene Expr       Date:  2008       Impact factor: 1.807
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