Literature DB >> 369877

Reactions of cysteine, its derivatives, glutathione coenzyme A, and dihydrolipoic acid with isothiocyanates.

D Podhradský, L Drobnica, P Kristian.   

Abstract

Isothiocyanates react with deprotonated SH groups of investigated compounds to give the esters of N-monosubstituted dithiocarbamic acid. In the presence of the SH and NH2 groups (Cys, GSH), isothiocyanates react primarily with the SH groups. The reactions are dependent on the pKa SH values.

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Year:  1979        PMID： 369877     DOI： 10.1007/bf01920581

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  2 in total

1.  A note on the combination of cysteine with allyl isothiocyanate.

Authors:  A Todrick; E Walker
Journal:  Biochem J       Date:  1937-02       Impact factor: 3.857

2.  Determination of the microscopic ionization constants of cysteine.

Authors:  G E Clement; T P Hartz
Journal:  J Chem Educ       Date:  1971-06       Impact factor: 2.979
  2 in total
  15 in total

1.  Identification of potential protein targets of isothiocyanates by proteomics.

Authors:  Lixin Mi; Brian L Hood; Nicolas A Stewart; Zhen Xiao; Sudha Govind; Xiantao Wang; Thomas P Conrads; Timothy D Veenstra; Fung-Lung Chung
Journal:  Chem Res Toxicol       Date:  2011-08-26       Impact factor: 3.739

2.  Cruciferous vegetables, isothiocyanates, and prevention of bladder cancer.

Authors:  Omkara L Veeranki; Arup Bhattacharya; Li Tang; James R Marshall; Yuesheng Zhang
Journal:  Curr Pharmacol Rep       Date:  2015-08

3.  Hydrogen sulfide protects colon cancer cells from chemopreventative agent beta-phenylethyl isothiocyanate induced apoptosis.

Authors:  Peter Rose; Philip-K Moore; Shen-Han Ming; Ong-Choon Nam; Jeffrey-S Armstrong; Matt Whiteman
Journal:  World J Gastroenterol       Date:  2005-07-14       Impact factor: 5.742

4.  Insights into the mode of action of benzyl isothiocyanate on Campylobacter jejuni.

Authors:  Virginie Dufour; Martin Stahl; Eric Rosenfeld; Alain Stintzi; Christine Baysse
Journal:  Appl Environ Microbiol       Date:  2013-09-06       Impact factor: 4.792

Review 5.  Proteins as binding targets of isothiocyanates in cancer prevention.

Authors:  Lixin Mi; Anthony J Di Pasqua; Fung-Lung Chung
Journal:  Carcinogenesis       Date:  2011-06-10       Impact factor: 4.944

6.  A cautionary note on using N-acetylcysteine as an antagonist to assess isothiocyanate-induced reactive oxygen species-mediated apoptosis.

Authors:  Lixin Mi; Paul Sirajuddin; Nanqin Gan; Xiantao Wang
Journal:  Anal Biochem       Date:  2010-06-10       Impact factor: 3.365

Review 7.  The molecular basis that unifies the metabolism, cellular uptake and chemopreventive activities of dietary isothiocyanates.

Authors:  Yuesheng Zhang
Journal:  Carcinogenesis       Date:  2011-11-10       Impact factor: 4.944

Review 8.  Proteomic identification of binding targets of isothiocyanates: A perspective on techniques.

Authors:  Lixin Mi; Zhen Xiao; Timothy D Veenstra; Fung-Lung Chung
Journal:  J Proteomics       Date:  2011-04-30       Impact factor: 4.044

9.  Sulforaphane inhibits multiple inflammasomes through an Nrf2-independent mechanism.

Authors:  Allison J Greaney; Nolan K Maier; Stephen H Leppla; Mahtab Moayeri
Journal:  J Leukoc Biol       Date:  2015-08-12       Impact factor: 4.962

Review 10.  Transduction of redox signaling by electrophile-protein reactions.

Authors:  Tanja K Rudolph; Bruce A Freeman
Journal:  Sci Signal       Date:  2009-09-29       Impact factor: 8.192
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