Literature DB >> 3697710

Reconnection of severed nerve axons with polyethylene glycol.

G D Bittner, M L Ballinger, M A Raymond.   

Abstract

Severed medial giant axons in crayfish can be rejoined in vitro with polyethylene glycol (PEG) to produce axoplasmic continuity and through transmission of action potentials. Severed axon-like processes of a mammalian neuroblastoma/glioma cell line seem to be rejoined to the cell body using PEG in tissue culture. Our data suggest that PEG might be used to rejoin severed axons in vivo in various organisms.

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Year:  1986        PMID： 3697710     DOI： 10.1016/0006-8993(86)91617-3

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  18 in total

1.  Rapid induction of functional and morphological continuity between severed ends of mammalian or earthworm myelinated axons.

Authors:  A B Lore; J A Hubbell; D S Bobb; M L Ballinger; K L Loftin; J W Smith; M E Smyers; H D Garcia; G D Bittner
Journal:  J Neurosci       Date:  1999-04-01       Impact factor: 6.167

2.  A novel therapy to promote axonal fusion in human digital nerves.

Authors:  Ravinder Bamba; Thanapong Waitayawinyu; Ratnam Nookala; David Colton Riley; Richard B Boyer; Kevin W Sexton; Chinnakart Boonyasirikool; Sunyarn Niempoog; Nathaniel D Kelm; Mark D Does; Richard D Dortch; Robert Bruce Shack; Wesley P Thayer
Journal:  J Trauma Acute Care Surg       Date:  2016-11       Impact factor: 3.313

3.  Preparation and preliminary characterization of poly(ethylene glycol)-pepstatin conjugate.

Authors:  J Brygier; J Vincentelli; M Nijs; C Guermant; C Paul; D Baeyens-Volant; Y Looze
Journal:  Appl Biochem Biotechnol       Date:  1994-04       Impact factor: 2.926

4.  Rapid morphological fusion of severed myelinated axons by polyethylene glycol.

Authors:  T L Krause; G D Bittner
Journal:  Proc Natl Acad Sci U S A       Date:  1990-02       Impact factor: 11.205

Review 5.  The curious ability of polyethylene glycol fusion technologies to restore lost behaviors after nerve severance.

Authors:  G D Bittner; D R Sengelaub; R C Trevino; J D Peduzzi; M Mikesh; C L Ghergherehchi; T Schallert; W P Thayer
Journal:  J Neurosci Res       Date:  2015-11-03       Impact factor: 4.164

6.  Affinity for, and localization of, PEG-functionalized silica nanoparticles to sites of damage in an ex vivo spinal cord injury model.

Authors:  Bojun Chen; Mahvash Zuberi; Richard Ben Borgens; Youngnam Cho
Journal:  J Biol Eng       Date:  2012-09-14       Impact factor: 4.355

7.  Partial restoration of spinal cord neural continuity via vascular pedicle hemisected spinal cord transplantation using spinal cord fusion technique.

Authors:  Xiaoping Ren; Weihua Zhang; Jie Qin; Jian Mo; Yi Chen; Jie Han; Xinjian Feng; Sitan Feng; Haibo Liang; Liangjue Cen; Xiaofei Wu; Linxuan Han; Rongyu Lan; Haixuan Deng; Huihui Yao; Zhongquan Qi; Hongjun Gao; Lishan Wei; Shuai Ren
Journal:  CNS Neurosci Ther       Date:  2022-05-12       Impact factor: 7.035

8.  HEAVEN: The head anastomosis venture Project outline for the first human head transplantation with spinal linkage (GEMINI).

Authors:  Sergio Canavero
Journal:  Surg Neurol Int       Date:  2013-06-13

Review 9.  A novel technique using hydrophilic polymers to promote axonal fusion.

Authors:  Ravinder Bamba; D Colton Riley; Nathaniel D Kelm; Mark D Does; Richard D Dortch; Wesley P Thayer
Journal:  Neural Regen Res       Date:  2016-04       Impact factor: 5.135

10.  Application and implications of polyethylene glycol-fusion as a novel technology to repair injured spinal cords.

Authors:  George D Bittner; Kiran K Rokkappanavar; Jean D Peduzzi
Journal:  Neural Regen Res       Date:  2015-09       Impact factor: 5.135
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