Literature DB >> 369651

Improved metabolic profiles in insulin-treated diabetic patients given an alpha-glucosidehydrolase inhibitor.

R J Walton, I T Sherif, G A Noy, K G Alberti.   

Abstract

An alpha-glucosidehydrolase inhibitor (acarbose; BAY g 5421) taken with food was compared with dummy tablets in seven insulin-treated diabetic patients over eight-hour periods that included breakfast, lunch, and two snacks. Acarbose diminished the postprandial increases in blood glucose, lactate, and pyruvate concentrations and may therefore be of value in the management of insulin-dependent diabetes.

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Year:  1979        PMID： 369651      PMCID： PMC1597843          DOI： 10.1136/bmj.1.6158.220

Source DB:  PubMed          Journal:  Br Med J        ISSN： 0007-1447


  6 in total

1.  [Diabetes mellitus and its degenerative complications: a prospective study of 4,400 patients observed between 1947 and 1973 (author's transl)].

Authors:  J Pirart
Journal:  Diabete Metab       Date:  1977-06

2.  alpha-Glucosidase inhibitors. New complex oligosaccharides of microbial origin.

Authors:  D D Schmidt; W Frommer; B Junge; L Müller; W Wingender; E Truscheit; D Schäfer
Journal:  Naturwissenschaften       Date:  1977-10

3.  Dietary fibres, fibre analogues, and glucose tolerance: importance of viscosity.

Authors:  D J Jenkins; T M Wolever; A R Leeds; M A Gassull; P Haisman; J Dilawari; D V Goff; G L Metz; K G Alberti
Journal:  Br Med J       Date:  1978-05-27

4.  Effect of multiple daily insulin injections on the course of diabetic retinopathy.

Authors:  E Eschwege; C Guyot-Argenton; J P Aubry; G Tchobroutsky
Journal:  Diabetes       Date:  1976-05       Impact factor: 9.461

5.  Sucrose malabsorption in man after ingestion of alpha-glucosidehydrolase inhibitor.

Authors:  W F Caspary
Journal:  Lancet       Date:  1978-06-10       Impact factor: 79.321

6.  Unabsorbable carbohydrates and diabetes: Decreased post-prandial hyperglycaemia.

Authors:  D J Jenkins; D V Goff; A R Leeds; K G Alberti; T M Wolever; M A Gassull; T D Hockaday
Journal:  Lancet       Date:  1976-07-24       Impact factor: 79.321
  6 in total
  20 in total

1.  Effect of acarbose on carbohydrate tolerance during administration of a fibre-free formula diet on healthy subjects.

Authors:  I E Walter-Sack; A Ittner-Holland; G Wolfram; N Zoellner
Journal:  Eur J Clin Pharmacol       Date:  1986       Impact factor: 2.953

2.  Effect of the alpha-glucosidase-inhibitor BAY-g-5421 on blood glucose control of sulphonylurea-treated diabetics and insulin-treated diabetics.

Authors:  G Sachse; B Willms
Journal:  Diabetologia       Date:  1979-11       Impact factor: 10.122

3.  Acute and short term effects of intestinal alpha-glucosidase inhibition on gut hormone responses in man.

Authors:  L O Uttenthal; O O Ukponmwan; M Ghiglione; S R Bloom
Journal:  Dig Dis Sci       Date:  1987-02       Impact factor: 3.199

4.  The effect of miglitol and acarbose after an oral glucose load: a novel hypoglycaemic mechanism?

Authors:  P H Joubert; H L Venter; G N Foukaridis
Journal:  Br J Clin Pharmacol       Date:  1990-09       Impact factor: 4.335

5.  The diabetic diet, dietary carbohydrate and differences in digestibility.

Authors:  D J Jenkins; R H Taylor; T M Wolever
Journal:  Diabetologia       Date:  1982-12       Impact factor: 10.122

6.  Glycogen storage disease type I. Results of treatment with frequent daytime feeding, combined with nocturnal intragastric feeding and with administration of an alpha-glucosidase inhibitor.

Authors:  H Gröbe; K Ullrich
Journal:  Eur J Pediatr       Date:  1983-04       Impact factor: 3.183

7.  Effect of a long-term acarbose therapy on the metabolic control of sulphonylurea-treated diabetic patients.

Authors:  G Sachse; H Laube; E Mäser; K Federlin
Journal:  Diabetologia       Date:  1982-03       Impact factor: 10.122

8.  Hyperglycemia induces intestinal sucrase activity in subtotally pancreatectomized rats.

Authors:  T Takeguchi; K Mori; S Takano; M Akagi
Journal:  Gastroenterol Jpn       Date:  1985-02

9.  Effects of two new alpha-glucosidase inhibitors on glycemic control in patients with insulin-dependent diabetes mellitus.

Authors:  G Dimitriadis; S Raptis; A Raptis; E Hatziagelaki; A Mitrakou; P Halvatsiotis; S Ladas; I Hillebrand
Journal:  Klin Wochenschr       Date:  1986-05-02

10.  Delaying carbohydrate absorption in noninsulin-dependent diabetes mellitus: useful therapy?

Authors:  H S Füessl
Journal:  Klin Wochenschr       Date:  1987-05-04
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