| Literature DB >> 3695505 |
J Kniewald1, M Peruzović, T Gojmerac, K Milković, Z Kniewald.
Abstract
Daily s.c. injections of atrazine and deethylatrazine to rat mothers during pregnancy only or during pregnancy and lactation influenced the pituitary-gonadal axis of male and female offsprings. In female and male offspring, slow maturation of gonadotropic system is evident and as a consequence modified male and female pituitary 5 alpha-R activity is present. The number of specific steroid-hormone receptor sites at the offsprings' gonads is unchanged if the mothers were treated only during pregnancy, but 5 alpha-DHT prostate receptors are strongly inhibited in offspring of mothers treated with atrazine and deethylatrazine during pregnancy and lactation.Entities:
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Year: 1987 PMID： 3695505 DOI： 10.1016/0022-4731(87)90195-6
Source DB: PubMed Journal: J Steroid Biochem ISSN： 0022-4731 Impact factor: 4.292