Literature DB >> 3692017

Effect of fusarochromanone and T-2 toxin on articular chondrocytes in monolayer culture.

G C Wright1, W F Marasas, L Sokoloff.   

Abstract

The effect of fusarochromanone and T-2 toxin on DNA synthesis and radio-sulfate incorporation by rabbit articular chondrocytes was studied in monolayer culture. T-2 toxin reduced DNA more than 50% at 5 x 10(-9) M; fusarochromanone caused small but progressive decrements over a range of 5 x 10(-8) to 10(-6) M. These actions are not specific for chondrocytes. The findings lend no support to the hypothesis that fusarochromanone, at least in unmodified form, is the etiologic agent in Kashin-Beck disease.

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Year:  1987        PMID： 3692017     DOI： 10.1016/0272-0590(87)90040-6

Source DB:  PubMed          Journal:  Fundam Appl Toxicol        ISSN： 0272-0590


  4 in total

Review 1.  Acquired chondronecrosis.

Authors:  L Sokoloff
Journal:  Ann Rheum Dis       Date:  1990-04       Impact factor: 19.103

2.  A survey of the occurrence of Fusarium mycotoxins (trichothecenes, zearalenone, and fusarochromanone) in corn and wheat samples from Shaanxi and Shanxi Provinces, China.

Authors:  Y Luo; T Yoshizawa; J S Yang; S Y Zhang; B J Zhang
Journal:  Mycotoxin Res       Date:  1992-09       Impact factor: 3.833

3.  Association study of polymorphisms in selenoprotein genes and Kashin-Beck disease and serum selenium/iodine concentration in a Tibetan population.

Authors:  Lulin Huang; Yi Shi; Fang Lu; Hong Zheng; Xiaoqi Liu; Bo Gong; Jiyun Yang; Ying Lin; Jing Cheng; Shi Ma; He Lin; Zhenglin Yang
Journal:  PLoS One       Date:  2013-08-23       Impact factor: 3.240

4.  Cellular responses to T-2 toxin and/or deoxynivalenol that induce cartilage damage are not specific to chondrocytes.

Authors:  Yang Lei; Zhao Guanghui; Wang Xi; Wang Yingting; Lin Xialu; Yu Fangfang; Mary B Goldring; Guo Xiong; Mikko J Lammi
Journal:  Sci Rep       Date:  2017-05-22       Impact factor: 4.379
  4 in total

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