Literature DB >> 3691803

The importance of the negative charge of beta-lactam compounds for the inactivation of the active-site serine DD-peptidase of Streptomyces R61.

L Varetto1, J M Frère, J M Ghuysen.   

Abstract

The interaction between the Streptomyces R61 penicillin-sensitive DD-peptidase and deacetyl-cephalosporin C or its lactone derivative has been studied at different pH values. The results show the importance of an enzyme group of pK approximately equal to 9 which might form an ion pair with the free carboxylate of the former compound. This electrostatic interaction is shown to contribute to the formation of the first, non-covalent enzyme-inactivator complex by a factor of at least 50.

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Year:  1987        PMID： 3691803     DOI： 10.1016/0014-5793(87)81161-4

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  6 in total

1.  Point mutations of two arginine residues in the Streptomyces R61 DD-peptidase.

Authors:  C Bourguignon-Bellefroid; B Joris; J Van Beeumen; J M Ghuysen; J M Frère
Journal:  Biochem J       Date:  1992-04-01       Impact factor: 3.857

2.  Sensitivity of Aeromonas hydrophila carbapenemase to delta3-cephems: comparative study with other metallo-beta-lactamases.

Authors:  A Felici; M Perilli; N Franceschini; G M Rossolini; M Galleni; J M Frere; A Oratore; G Amicosante
Journal:  Antimicrob Agents Chemother       Date:  1997-04       Impact factor: 5.191

3.  Importance of the His-298 residue in the catalytic mechanism of the Streptomyces R61 extracellular DD-peptidase.

Authors:  A M Hadonou; M Jamin; M Adam; B Joris; J Dusart; J M Ghuysen; J M Frère
Journal:  Biochem J       Date:  1992-03-01       Impact factor: 3.857

4.  The importance of the negative charge of beta-lactam compounds in the interactions with active-site serine DD-peptidases and beta-lactamases.

Authors:  L Varetto; F De Meester; D Monnaie; J Marchand-Brynaert; G Dive; F Jacob; J M Frère
Journal:  Biochem J       Date:  1991-09-15       Impact factor: 3.857

5.  Penicillin acylase mutants with altered site-directed activity from Kluyvera citrophila.

Authors:  I Prieto; J Martín; R Arche; P Fernández; A Pérez-Aranda; J L Barbero
Journal:  Appl Microbiol Biotechnol       Date:  1990-08       Impact factor: 4.813

6.  Studies at the ionizable position of cephalosporins and penicillins: hydroxamates as substitutes for the traditional carboxylate group.

Authors:  Mark W Majewski; Patricia A Miller; Marvin J Miller
Journal:  J Antibiot (Tokyo)       Date:  2016-12-21       Impact factor: 2.649
  6 in total

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