Literature DB >> 3690833

Adenylosuccinate lyase as an indicator of breast and prostate malignancies: a preliminary report.

V L Reed1, D O Mack, L D Smith.   

Abstract

The high activity of adenylosuccinate (SAMP) lyase found in rat breast tumor, and its relative absence from normal rat breast tissue, suggests that it may serve as an indicator for human breast malignancy. Its activity has been measured in human breast tumors, both malignant and benign. The two were clearly separated with no overlap in activity between the malignant and benign tissues. Human prostate tissues were also examined for SAMP lyase. A cut-off level of 5 U/mL gave a false-positive rate of 11% with no false negatives. These results indicate that further work is warranted to determine the effectiveness of SAMP lyase as an indicator of breast and prostatic cancers.

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Year:  1987        PMID： 3690833     DOI： 10.1016/s0009-9120(87)80085-1

Source DB:  PubMed          Journal:  Clin Biochem        ISSN： 0009-9120            Impact factor:   3.281


  6 in total

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2.  Adenylosuccinate lyase enhances aggressiveness of endometrial cancer by increasing killer cell lectin-like receptor C3 expression by fumarate.

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Journal:  Lab Invest       Date:  2018-02-21       Impact factor: 5.662

3.  Cryptococcus neoformans ADS lyase is an enzyme essential for virulence whose crystal structure reveals features exploitable in antifungal drug design.

Authors:  Jessica L Chitty; Kirsten L Blake; Ross D Blundell; Y Q Andre E Koh; Merinda Thompson; Avril A B Robertson; Mark S Butler; Matthew A Cooper; Ulrike Kappler; Simon J Williams; Bostjan Kobe; James A Fraser
Journal:  J Biol Chem       Date:  2017-05-30       Impact factor: 5.157

4.  Molecular cloning, characterization and expression analysis of adenylosuccinate lyase gene in grass carp (Ctenopharyngodon idella).

Authors:  Tian Yuan; Ji-Rui Gu; Wen-Bo Gu; Jiang Wu; Shao-Rong Ge; Heng Xu
Journal:  Mol Biol Rep       Date:  2010-09-21       Impact factor: 2.316

5.  Targeting the De Novo Purine Synthesis Pathway Through Adenylosuccinate Lyase Depletion Impairs Liver Cancer Growth by Perturbing Mitochondrial Function.

Authors:  Tingting Jiang; Francisco J Sánchez-Rivera; Yadira M Soto-Feliciano; Qiyuan Yang; Chun-Qing Song; Arjun Bhuatkar; Cole M Haynes; Michael T Hemann; Wen Xue
Journal:  Hepatology       Date:  2021-07-12       Impact factor: 17.298

6.  Prolyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple negative breast cancer.

Authors:  Giada Zurlo; Xijuan Liu; Mamoru Takada; Cheng Fan; Jeremy M Simon; Travis S Ptacek; Javier Rodriguez; Alex von Kriegsheim; Juan Liu; Jason W Locasale; Adam Robinson; Jing Zhang; Jessica M Holler; Baek Kim; Marie Zikánová; Jörgen Bierau; Ling Xie; Xian Chen; Mingjie Li; Charles M Perou; Qing Zhang
Journal:  Nat Commun       Date:  2019-11-15       Impact factor: 14.919
  6 in total

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