| Literature DB >> 3689367 |
S P Perrine1, B A Miller, M F Greene, R A Cohen, N Cook, C Shackleton, D V Faller.
Abstract
The gamma----beta globin gene switch in humans is normally on a set developmental clock but is delayed in infants of diabetic mothers. We cultured cord blood erythroid progenitors and assayed globin produced in the presence and absence of metabolites that are elevated in such infants. Analogues of butyric acid at supranormal concentrations significantly augmented gamma and inhibited beta globin expression. The uptake of alpha-amino-n-butyric acid into colony-derived erythroblasts was increased in the presence of supranormal insulin. These findings suggest that elevated levels of alpha-amino-n-butyric acid and insulin in the developing fetus delay the globin switch and may offer potential for augmenting gamma globin expression in the beta globin chain diseases.Entities:
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Year: 1987 PMID： 3689367 DOI： 10.1016/0006-291x(87)90932-6
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575