Literature DB >> 3689001

A new promising treatment in systemic sclerosis: 5-fluorouracil.

J A Casas1, C P Subauste, G S Alarcón.   

Abstract

Twelve patients with systemic sclerosis according to American Rheumatism Association criteria were treated with intravenous 5-fluorouracil. Significant subjective and objective improvement occurred initially in the skin and subsequently in the involved viscera and vasculature. These preliminary results suggest that 5-fluorouracil may be an effective treatment for systemic sclerosis.

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Year:  1987        PMID： 3689001      PMCID： PMC1003384          DOI： 10.1136/ard.46.10.763

Source DB:  PubMed          Journal:  Ann Rheum Dis        ISSN： 0003-4967            Impact factor:   19.103


  5 in total

1.  The toxicity of D-penicillamine in systemic sclerosis.

Authors:  V D Steen; S Blair; T A Medsger
Journal:  Ann Intern Med       Date:  1986-05       Impact factor: 25.391

Review 2.  [Treatment of scleroderma].

Authors:  L Guillevin; J P Ortonne
Journal:  Ann Med Interne (Paris)       Date:  1983

3.  Skin capillary changes in early systemic scleroderma. Electron microscopy and "in vitro" autoradiography with tritiated thymidine.

Authors:  R Fleischmajer; J S Perlish; K V Shaw; D J Pirozzi
Journal:  Arch Dermatol       Date:  1976-11

4.  Clinical and serological comparison of 17 chronic progressive systemic sclerosis (PSS) and 17 CREST syndrome patients matched for sex, age, and disease duration.

Authors:  D E Furst; P J Clements; M Saab; M G Sterz; H E Paulus
Journal:  Ann Rheum Dis       Date:  1984-12       Impact factor: 19.103

5.  D-Penicillamine therapy in progressive systemic sclerosis (scleroderma): a retrospective analysis.

Authors:  V D Steen; T A Medsger; G P Rodnan
Journal:  Ann Intern Med       Date:  1982-11       Impact factor: 25.391
  5 in total
  9 in total

1.  European multicentre study to define disease activity criteria for systemic sclerosis. II. Identification of disease activity variables and development of preliminary activity indexes.

Authors:  G Valentini; A Della Rossa; S Bombardieri; W Bencivelli; A J Silman; S D'Angelo; M M Cerinic; J F Belch; C M Black; P Bruhlmann; L Czirják; A De Luca; A A Drosos; C Ferri; A Gabrielli; R Giacomelli; G Hayem; M Inanc; N J McHugh; H Nielsen; M Rosada; R Scorza; J Stork; A Sysa; F H van den Hoogen; P J Vlachoyiannopoulos
Journal:  Ann Rheum Dis       Date:  2001-06       Impact factor: 19.103

2.  5-fluorouracil in the treatment of scleroderma: a randomised, double blind, placebo controlled international collaborative study.

Authors:  J A Casas; P A Saway; I Villarreal; C Nolte; B L Menajovsky; E E Escudero; W D Blackburn; G S Alarcón; C P Subauste
Journal:  Ann Rheum Dis       Date:  1990-11       Impact factor: 19.103

Review 3.  Systemic sclerosis: is there a treatment yet?

Authors:  C M Black
Journal:  Ann Rheum Dis       Date:  1990-09       Impact factor: 19.103

Review 4.  Effects of immunomodulating therapy in systemic sclerosis.

Authors:  F H van den Hoogen; A M Boerbooms; L B van de Putte
Journal:  Clin Rheumatol       Date:  1990-09       Impact factor: 2.980

5.  5-Fluorouracil in progressive systemic sclerosis: is it safe?

Authors:  A N Malaviya; R R Singh; A Dhar; Y K Gupta; A Kumar; P Agarwal; R Mathur; N K Bhide
Journal:  Ann Rheum Dis       Date:  1988-11       Impact factor: 19.103

6.  An Update on the Treatment of the Cutaneous Manifestations of Systemic Sclerosis: The Dermatologist's Point of View.

Authors:  Magalys Vitiello; Adriana Abuchar; Néstor Santana; Luis Dehesa; Francisco A Kerdel
Journal:  J Clin Aesthet Dermatol       Date:  2012-07

7.  Diastolic abnormalities in systemic sclerosis: evidence for associated defective cardiac functional reserve.

Authors:  G Valentini; D F Vitale; A Giunta; S Maione; G Gerundo; M Arnese; E Tirri; N Pelaggi; A Giacummo; G Tirri; M Condorelli
Journal:  Ann Rheum Dis       Date:  1996-07       Impact factor: 19.103

8.  Proximal stomach function in systemic sclerosis: relationship with autonomic nerve function.

Authors:  P Iovino; G Valentini; C Ciacci; A De Luca; F Tremolaterra; F Sabbatini; E Tirri; G Mazzacca
Journal:  Dig Dis Sci       Date:  2001-04       Impact factor: 3.199

9.  Transcutaneous oxygen pressure in systemic sclerosis: evaluation at different sensor temperatures and relationship to skin perfusion.

Authors:  G Valentini; G Leonardo; D A Moles; M R Apaia; R Maselli; G Tirri; R Del Guercio
Journal:  Arch Dermatol Res       Date:  1991       Impact factor: 3.017
  9 in total

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