Literature DB >> 3685976

A cell-cycle constraint on the regulation of gene expression by platelet-derived growth factor.

B J Rollins1, E D Morrison, C D Stiles.   

Abstract

In density-arrested monolayer cultures of Balb/c 3T3 cells, platelet-derived growth factor (PDGF) stimulates expression of the c-myc and c-fos proto-oncogenes, as well as the functionally uncharacterized genes, JE, KC, and JB. These genes are not coordinately regulated. Under ordinary conditions, c-fos, JE, KC, and JB respond to PDGF only when the cells are in a state of G0 growth arrest at the time of PDGF addition. The c-myc gene is regulated in opposition to the other genes, responding best to PDGF in cycling cultures.

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Year:  1987        PMID： 3685976     DOI： 10.1126/science.3685976

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  9 in total

1.  Identification of the serum-responsive transcription initiation site of the zinc finger gene Krox-20.

Authors:  J Cortner; P J Farnham
Journal:  Mol Cell Biol       Date:  1990-07       Impact factor: 4.272

2.  The c-myc-regulated gene mrl encodes plasminogen activator inhibitor 1.

Authors:  G C Prendergast; L E Diamond; D Dahl; M D Cole
Journal:  Mol Cell Biol       Date:  1990-03       Impact factor: 4.272

Review 3.  Expression of the genes of interferons and other cytokines in normal and diseased tissues of man.

Authors:  M G Tovey
Journal:  Experientia       Date:  1989-06-15

4.  Platelet-derived growth factor-stimulated expression of the MCP-1 immediate-early gene involves an inhibitory multiprotein complex.

Authors:  P Sridhar; Y Liu; L D Chin; C E Borja; M Mann; H A Skopicki; R R Freter
Journal:  Mol Cell Biol       Date:  1999-06       Impact factor: 4.272

5.  The human homolog of the JE gene encodes a monocyte secretory protein.

Authors:  B J Rollins; P Stier; T Ernst; G G Wong
Journal:  Mol Cell Biol       Date:  1989-11       Impact factor: 4.272

6.  Human monocyte colony-stimulating factor stimulates the gene expression of monocyte chemotactic protein-1 and increases the adhesion of monocytes to endothelial monolayers.

Authors:  Y J Shyy; L L Wickham; J P Hagan; H J Hsieh; Y L Hu; S H Telian; A J Valente; K L Sung; S Chien
Journal:  J Clin Invest       Date:  1993-10       Impact factor: 14.808

7.  Cloning and expression of JE, a gene inducible by platelet-derived growth factor and whose product has cytokine-like properties.

Authors:  B J Rollins; E D Morrison; C D Stiles
Journal:  Proc Natl Acad Sci U S A       Date:  1988-06       Impact factor: 11.205

8.  Determinants that contribute to cytoplasmic stability of human c-fos and beta-globin mRNAs are located at several sites in each mRNA.

Authors:  K S Kabnick; D E Housman
Journal:  Mol Cell Biol       Date:  1988-08       Impact factor: 4.272

9.  Wound-factor-induced and cell cycle phase-dependent expression of 9E3/CEF4, the avian gro gene.

Authors:  M Martins-Green; C Tilley; R Schwarz; C Hatier; M J Bissell
Journal:  Cell Regul       Date:  1991-09
  9 in total

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