Literature DB >> 2406566

The c-myc-regulated gene mrl encodes plasminogen activator inhibitor 1.

G C Prendergast1, L E Diamond, D Dahl, M D Cole.   

Abstract

The DNA sequence of the c-myc-regulated gene mrl (G. C. Prendergast and M. D. Cole, Mol. Cell. Biol. 9:124-134, 1989) reveals that it encodes plasminogen activator inhibitor 1 (PAI-1), a regulator of extracellular proteolysis. Comparison of the human and mouse PAI-1 promoters and cDNA 3' noncoding regions revealed several highly conserved sequence domains, potential targets for c-myc and other factors influencing PAI-1 expression. We discuss possible roles for PAI-1 in normal and neoplastic cell growth control.

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Year:  1990        PMID： 2406566      PMCID： PMC361018          DOI： 10.1128/mcb.10.3.1265-1269.1990

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  33 in total

1.  Regulation of the fibrinolytic system of cultured human vascular endothelium by interleukin 1.

Authors:  M P Bevilacqua; R R Schleef; M A Gimbrone; D J Loskutoff
Journal:  J Clin Invest       Date:  1986-08       Impact factor: 14.808

2.  Cloning and sequence of a cDNA coding for the human beta-migrating endothelial-cell-type plasminogen activator inhibitor.

Authors:  T Ny; M Sawdey; D Lawrence; J L Millan; D J Loskutoff
Journal:  Proc Natl Acad Sci U S A       Date:  1986-09       Impact factor: 11.205

3.  Two apparent human endothelial cell growth factors from human hepatoma cells are tumor-associated proteinase inhibitors.

Authors:  W L McKeehan; Y Sakagami; H Hoshi; K A McKeehan
Journal:  J Biol Chem       Date:  1986-04-25       Impact factor: 5.157

4.  The dexamethasone-induced inhibitor of plasminogen activator in hepatoma cells is antigenically-related to an inhibitor produced by bovine aortic endothelial cells.

Authors:  D J Loskutoff; K Roegner; L A Erickson; R R Schleef; A Huttenlocher; P L Coleman; T D Gelehrter
Journal:  Thromb Haemost       Date:  1986-02-28       Impact factor: 5.249

5.  Identification of growth-factor-inducible genes in mouse fibroblasts.

Authors:  R Bravo; M Zerial; L Toschi; M Schürmann; R Müller; S I Hirai; M Yaniv; J M Almendral; R P Ryseck
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1988

Review 6.  Animal cell cycle.

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Journal:  Annu Rev Biochem       Date:  1978       Impact factor: 23.643

Review 7.  The regulation and expression of c-myc in normal and malignant cells.

Authors:  K Kelly; U Siebenlist
Journal:  Annu Rev Immunol       Date:  1986       Impact factor: 28.527

8.  Purification of an inhibitor of plasminogen activator (antiactivator) synthesized by endothelial cells.

Authors:  J A van Mourik; D A Lawrence; D J Loskutoff
Journal:  J Biol Chem       Date:  1984-12-10       Impact factor: 5.157

9.  Thrombin induction of plasminogen activator-inhibitor in cultured human endothelial cells.

Authors:  T D Gelehrter; R Sznycer-Laszuk
Journal:  J Clin Invest       Date:  1986-01       Impact factor: 14.808

10.  The primary plasminogen-activator inhibitors in endothelial cells, platelets, serum, and plasma are immunologically related.

Authors:  L A Erickson; C M Hekman; D J Loskutoff
Journal:  Proc Natl Acad Sci U S A       Date:  1985-12       Impact factor: 11.205
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  34 in total

1.  New nucleotide sequence data on the EMBL File Server.

Authors: 
Journal:  Nucleic Acids Res       Date:  1990-08-25       Impact factor: 16.971

2.  Transcriptomic Analysis of Cellular Pathways in Healing Flexor Tendons of Plasminogen Activator Inhibitor 1 (PAI-1/Serpine1) Null Mice.

Authors:  Margaret A T Freeberg; Anas Easa; Jacquelyn A Lillis; Danielle S W Benoit; Andre J van Wijnen; Hani A Awad
Journal:  J Orthop Res       Date:  2019-09-01       Impact factor: 3.494

Review 3.  c-Myc target genes involved in cell growth, apoptosis, and metabolism.

Authors:  C V Dang
Journal:  Mol Cell Biol       Date:  1999-01       Impact factor: 4.272

4.  Plasminogen deficiency accelerates vessel wall disease in mice predisposed to atherosclerosis.

Authors:  Q Xiao; M J Danton; D P Witte; M C Kowala; M T Valentine; T H Bugge; J L Degen
Journal:  Proc Natl Acad Sci U S A       Date:  1997-09-16       Impact factor: 11.205

5.  Changes in procoagulant and fibrinolytic gene expression during bleomycin-induced lung injury in the mouse.

Authors:  M A Olman; N Mackman; C L Gladson; K M Moser; D J Loskutoff
Journal:  J Clin Invest       Date:  1995-09       Impact factor: 14.808

6.  Targeted disruption of the mouse rho-associated kinase 2 gene results in intrauterine growth retardation and fetal death.

Authors:  Dean Thumkeo; Jeongsin Keel; Toshimasa Ishizaki; Masaya Hirose; Kimiko Nonomura; Hiroko Oshima; Masanobu Oshima; Makoto M Taketo; Shuh Narumiya
Journal:  Mol Cell Biol       Date:  2003-07       Impact factor: 4.272

7.  Transforming growth factor beta 1-responsive element: closely associated binding sites for USF and CCAAT-binding transcription factor-nuclear factor I in the type 1 plasminogen activator inhibitor gene.

Authors:  A Riccio; P V Pedone; L R Lund; T Olesen; H S Olsen; P A Andreasen
Journal:  Mol Cell Biol       Date:  1992-04       Impact factor: 4.272

8.  Fibrin deposition in tissues from endotoxin-treated mice correlates with decreases in the expression of urokinase-type but not tissue-type plasminogen activator.

Authors:  K Yamamoto; D J Loskutoff
Journal:  J Clin Invest       Date:  1996-06-01       Impact factor: 14.808

9.  Type 1 plasminogen activator inhibitor gene expression following partial hepatectomy.

Authors:  J Schneiderman; M Sawdey; H Craig; T Thinnes; G Bordin; D J Loskutoff
Journal:  Am J Pathol       Date:  1993-09       Impact factor: 4.307

10.  Species-specific differential cleavage and polyadenylation of plasminogen activator inhibitor type 1 hnRNA.

Authors:  P G Fattal; J J Billadello
Journal:  Nucleic Acids Res       Date:  1993-03-25       Impact factor: 16.971
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