Literature DB >> 3684842

Profound hypotension after the first dose of ketanserin.

P C Waller1, H A Cameron, L E Ramsay.   

Abstract

Two patients developed profound hypotension approximately one hour after taking an initial oral dose of ketanserin 40 mg. The reaction appeared similar to that reported with prazosin, and may have been due to the alpha 1-adrenoceptor antagonist action of ketanserin. Both patients were taking regular beta-blocker therapy, which may exacerbate such a reaction.

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Year:  1987        PMID： 3684842      PMCID： PMC2428148          DOI： 10.1136/pgmj.63.738.305

Source DB:  PubMed          Journal:  Postgrad Med J        ISSN： 0032-5473            Impact factor:   2.401


  11 in total

1.  Side effects due to treatment of hypertension with prazosin.

Authors:  M J Bendall; K H Baloch; P R Wilson
Journal:  Br Med J       Date:  1975-06-28

2.  Mechanism of antihypertensive action of ketanserin in man.

Authors:  I W Reimann; J C Frölich
Journal:  Br Med J (Clin Res Ed)       Date:  1983-08-06

3.  Treatment of hypertension with ketanserin, a new selective 5-HT2 receptor antagonist.

Authors:  G J Wenting; A J Man in 't Veld; A J Woittiez; F Boomsma; M A Schalekamp
Journal:  Br Med J (Clin Res Ed)       Date:  1982-02-20

4.  Studies on the clinical pharmacology of prazosin. I: Cardiovascular, catecholamine and endocrine changes following a single dose.

Authors:  P C Rubin; T F Blaschke
Journal:  Br J Clin Pharmacol       Date:  1980-07       Impact factor: 4.335

5.  Immediate cardiovascular responses to oral prazosin--effects of concurrent beta-blockers.

Authors:  H L Elliott; K McLean; D J Sumner; P A Meredith; J L Reid
Journal:  Clin Pharmacol Ther       Date:  1981-03       Impact factor: 6.875

6.  Prazosin first dose phenomenon during combined treatment with a beta-adrenoceptor blocker in hypertensive patients.

Authors:  P Seideman; A Grahnén; K Haglund; B Lindström; C Von Bahr
Journal:  Br J Clin Pharmacol       Date:  1982-06       Impact factor: 4.335

7.  Ketanserin in essential hypertension: a double-blind, placebo-controlled study.

Authors:  H A Cameron; L E Ramsay
Journal:  Postgrad Med J       Date:  1985-07       Impact factor: 2.401

8.  5-HT, alpha-adrenoceptors, and blood pressure. Effects of ketanserin in essential hypertension and autonomic insufficiency.

Authors:  G J Wenting; A J Woittiez; A J Man in't Veld; M A Schalekamp
Journal:  Hypertension       Date:  1984 Jan-Feb       Impact factor: 10.190

9.  Ketanserin in hypertension. Early clinical evaluation and dose finding study of a new 5-HT2 receptor antagonist.

Authors:  L Andrén; A Svensson; B Dahlöf; R Eggertsen; L Hansson
Journal:  Acta Med Scand       Date:  1983

10.  Comparison of single doses of ketanserin and placebo in chronic stable angina.

Authors:  H A Cameron; C M Cameron; L E Ramsay
Journal:  Br J Clin Pharmacol       Date:  1986-07       Impact factor: 4.335
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  2 in total

1.  'First dose' hypotension and venodilatation.

Authors:  S Capewell; A Capewell
Journal:  Br J Clin Pharmacol       Date:  1991-02       Impact factor: 4.335

Review 2.  Ketanserin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in hypertension and peripheral vascular disease.

Authors:  R N Brogden; E M Sorkin
Journal:  Drugs       Date:  1990-12       Impact factor: 9.546
  2 in total

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