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Literature DB >> 368041

Accumulation of peptidyl tRNA is lethal to Escherichia coli.

Abstract

A mutant strain of Escherichia coli with temperature-sensitive peptidyl-tRNA hydrolase grows at 30 degrees C but, when shifted to 40 degrees C, dies at rates affected by physiological, pharmacological, and genetical perturbations. The rate of killing correlates with the relative accumulation of peptidyl-tRNA, suggesting that it is responsible for the death of the cells.

Entities: Gene Species

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Year: 1979 PMID： 368041 PMCID： PMC218507 DOI： 10.1128/jb.137.1.694-696.1979

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

5 in total

1. Peptidyl transfer RNA dissociates during protein synthesis from ribosomes of Escherichia coli.

Authors: J R Menninger
Journal: J Biol Chem Date: 1976-06-10 Impact factor: 5.157

2. The accumulation as peptidyl-transfer RNA of isoaccepting transfer RNA families in Escherichia coli with temperature-sensitive peptidyl-transfer RNA hydrolase.

Authors: J R Menninger
Journal: J Biol Chem Date: 1978-10-10 Impact factor: 5.157

3. Mutant E. coli strain with temperature sensitive peptidyl-transfer RNA hydrolase.

Authors: A G Atherly; J R Menninger
Journal: Nat New Biol Date: 1972-12-20

4. Studies on the metabolic role of peptidyl-tRNA hydrolase. I. Properties of a mutant E. coli with temperature-sensitive peptidyl-tRNA hydrolase.

Authors: J R Menninger; C Walker; P F Tan
Journal: Mol Gen Genet Date: 1973-03-19

5. Release of (oligo) peptidyl-tRNA from ribosomes by erythromycin A.

Authors: T Otaka; A Kaji
Journal: Proc Natl Acad Sci U S A Date: 1975-07 Impact factor: 11.205

5 in total

39 in total

1. Molecular basis for the temperature sensitivity of Escherichia coli pth(Ts).

Authors: L R Cruz-Vera; I Toledo; J Hernández-Sánchez; G Guarneros
Journal: J Bacteriol Date: 2000-03 Impact factor: 3.490

2. Crystallization and preliminary X-ray analysis of peptidyl-tRNA hydrolase from Escherichia coli in complex with the acceptor-TΨC domain of tRNA.

Authors: Kosuke Ito; Hao Qi; Yoshihiro Shimizu; Ryo Murakami; Kin-ichiro Miura; Takuya Ueda; Toshio Uchiumi
Journal: Acta Crystallogr Sect F Struct Biol Cryst Commun Date: 2011-11-26

3. Analysis of aminoacyl- and peptidyl-tRNAs by gel electrophoresis.

Authors: Brian D Janssen; Elie J Diner; Christopher S Hayes
Journal: Methods Mol Biol Date: 2012

4. Inhibition of translation and cell growth by minigene expression.

Authors: T Tenson; J V Herrera; P Kloss; G Guarneros; A S Mankin
Journal: J Bacteriol Date: 1999-03 Impact factor: 3.490

5. Antibiotic inducibility of the MexXY multidrug efflux system of Pseudomonas aeruginosa: involvement of the antibiotic-inducible PA5471 gene product.

Authors: Yuji Morita; Mara L Sobel; Keith Poole
Journal: J Bacteriol Date: 2006-03 Impact factor: 3.490

6. Release factor RF-3 GTPase activity acts in disassembly of the ribosome termination complex.

Authors: G Grentzmann; P J Kelly; S Laalami; M Shuda; M A Firpo; Y Cenatiempo; A Kaji
Journal: RNA Date: 1998-08 Impact factor: 4.942

7. Laboratory evolution and multi-platform genome re-sequencing of the cellulolytic actinobacterium Thermobifida fusca.

Authors: Yu Deng; Stephen S Fong
Journal: J Biol Chem Date: 2011-09-13 Impact factor: 5.157

8. Ribosome release factor RF4 and termination factor RF3 are involved in dissociation of peptidyl-tRNA from the ribosome.

Authors: V Heurgué-Hamard; R Karimi; L Mora; J MacDougall; C Leboeuf; G Grentzmann; M Ehrenberg; R H Buckingham
Journal: EMBO J Date: 1998-02-02 Impact factor: 11.598

9. Ribosomal release without peptidyl tRNA hydrolysis at translation termination in a eukaryotic system.

Authors: J Cao; A P Geballe
Journal: RNA Date: 1998-02 Impact factor: 4.942

10. Crystal structure at 1.2 A resolution and active site mapping of Escherichia coli peptidyl-tRNA hydrolase.

Authors: E Schmitt; Y Mechulam; M Fromant; P Plateau; S Blanquet
Journal: EMBO J Date: 1997-08-01 Impact factor: 11.598