Literature DB >> 3680028

Macrolide biosynthesis: stereochemistry of the hydroxylation of brefeldin C.

M Gonzalez de la Parra1, C R Hutchinson.   

Abstract

Brefeldin C (2) is the penultimate intermediate in the biosynthetic pathway to brefeldin A (1). Using stereospecifically 2H-labeled forms of 2, the hydroxylation of 2 to 1 is shown to involve stereospecific removal of the 7 pro-S hydrogen from 2.

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Year:  1987        PMID: 3680028     DOI: 10.7164/antibiotics.40.1170

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN: 0021-8820            Impact factor:   2.649


  3 in total

1.  Production of brefeldin-A.

Authors:  T G McCloud; M P Burns; F D Majadly; G M Muschik; D A Miller; K K Poole; J M Roach; J T Ross; W B Lebherz
Journal:  J Ind Microbiol       Date:  1995-07

2.  Ultrastructural characteristics of TSH-producing adenomas with special reference to its close similarity to BFA-treated pituitary adenoma cells.

Authors:  H Ikeda; Y Ogawa; T Yoshimoto
Journal:  Pituitary       Date:  1999-05       Impact factor: 4.107

3.  Fungal polyketide synthase product chain-length control by partnering thiohydrolase.

Authors:  Angelica O Zabala; Yit-Heng Chooi; Moon Seok Choi; Hsiao-Ching Lin; Yi Tang
Journal:  ACS Chem Biol       Date:  2014-05-29       Impact factor: 5.100

  3 in total

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