Literature DB >> 3678142

Insulin-like growth factor gene expression during rat embryonic development.

P Rotwein1, K M Pollock, M Watson, J D Milbrandt.   

Abstract

The function of insulin-like growth factors I and II (IGF-I and IGF-II) in embryogenesis is unknown. To investigate the ontogeny of IGF gene expression during mammalian development we used a highly sensitive and specific solution-hybridization assay to determine the steady state levels of IGF mRNAs during midgestation in the rat. IGF-I mRNA can be detected as early as day 11 of embryonic development and rises 8.6-fold over the ensuing 48 h. By contrast IGF-II mRNA is relatively constant over days 11-14 of gestation. These observations suggest that both IGFs may play important roles in early fetal development.

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Year:  1987        PMID： 3678142     DOI： 10.1210/endo-121-6-2141

Source DB:  PubMed          Journal:  Endocrinology        ISSN： 0013-7227            Impact factor:   4.736


  14 in total

Review 1.  Polypeptide growth factors and the kidney: a developmental perspective.

Authors:  E D Avner
Journal:  Pediatr Nephrol       Date:  1990-07       Impact factor: 3.714

Review 2.  The complexity of the IGF1 gene splicing, posttranslational modification and bioactivity.

Authors:  Anastassios Philippou; Maria Maridaki; Spiros Pneumaticos; Michael Koutsilieris
Journal:  Mol Med       Date:  2014-05-07       Impact factor: 6.354

3.  Growth promoting effects of human placental lactogen during early organogenesis: a link to insulin-like growth factors.

Authors:  A K Karabulut; R Layfield; M K Pratten
Journal:  J Anat       Date:  2001-06       Impact factor: 2.610

4.  Insulin-like growth factor I expression by tumors of neuroectodermal origin with the t(11;22) chromosomal translocation. A potential autocrine growth factor.

Authors:  D Yee; R E Favoni; G S Lebovic; F Lombana; D R Powell; C P Reynolds; N Rosen
Journal:  J Clin Invest       Date:  1990-12       Impact factor: 14.808

5.  Enhanced insulin-like growth factor I gene expression in regenerating rat pancreas.

Authors:  F E Smith; K M Rosen; L Villa-Komaroff; G C Weir; S Bonner-Weir
Journal:  Proc Natl Acad Sci U S A       Date:  1991-07-15       Impact factor: 11.205

6.  Production of IGF-II-related peptide by an anaplastic cell line (AT-3) established from the Dunning prostatic carcinoma of rats.

Authors:  Y Matuo; N Nishi; H Tanaka; I Sasaki; J T Isaacs; F Wada
Journal:  In Vitro Cell Dev Biol       Date:  1988-10

7.  Development of primary culture of ovine fetal hepatocytes for studies of amino acid metabolism and insulinlike growth factors.

Authors:  S F Townsend; P J Thureen; W W Hay; M R Narkewicz
Journal:  In Vitro Cell Dev Biol Anim       Date:  1993-07       Impact factor: 2.416

8.  Expression of insulin-like growth factor I gene in osmoregulatory organs during seawater adaptation of the salmonid fish: possible mode of osmoregulatory action of growth hormone.

Authors:  T Sakamoto; T Hirano
Journal:  Proc Natl Acad Sci U S A       Date:  1993-03-01       Impact factor: 11.205

9.  Focal expression of insulin-like growth factor I in rat kidney collecting duct.

Authors:  J D Bortz; P Rotwein; D DeVol; P J Bechtel; V A Hansen; M R Hammerman
Journal:  J Cell Biol       Date:  1988-08       Impact factor: 10.539

10.  A role for Insulin-like growth factor 2 in specification of the fast skeletal muscle fibre.

Authors:  Deborah Merrick; Tao Ting; Lukas Kurt Josef Stadler; Janet Smith
Journal:  BMC Dev Biol       Date:  2007-06-08       Impact factor: 1.978
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