Literature DB >> 3677596

Glutathione and lipid peroxidation in the aging rat.

M Y Farooqui1, W W Day, D M Zamorano.   

Abstract

1. Tissue extracts were prepared from liver, kidney, heart, brain, lung and spleen of male Sprague-Dawley rats of different ages (1-36 months); each of the extracts was analyzed for reduced glutathione (GSH) and lipid peroxides. 2. At all ages the GSH content in the liver was 3-10 times higher than that in other tissues. 3. In the old (36 months) rat the GSH content of all the tissues studied were lower (35-60%) than that in 2.5 month old rat. 4. The lipid peroxides levels increased by age in all tissues studied. 5. These findings indicate that general characteristics of aging tissue may include a decrease in GSH content and increase in lipid peroxides showing a decrease in reducing potential in senescence.

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Year:  1987        PMID： 3677596     DOI： 10.1016/0305-0491(87)90097-6

Source DB:  PubMed          Journal:  Comp Biochem Physiol B        ISSN： 0305-0491


  19 in total

1.  Age related changes in lipid peroxidation and antioxidants in elderly people.

Authors:  V Prashant Akila; H Harishchandra; Vivian D'souza; Benedicta D'souza
Journal:  Indian J Clin Biochem       Date:  2007-03

2.  Effects of ageing on metabolite and oxidant concentrations in different regions of rat kidney under normal and stress conditions.

Authors:  Noor Riyadh Thiab; Nicola King; Graham L Jones
Journal:  Mol Cell Biochem       Date:  2015-06-23       Impact factor: 3.396

3.  Effect of procysteine on aging-associated changes in hepatic GSH and SMase: evidence for transcriptional regulation of smpd3.

Authors:  Gergana Deevska; Manjula Sunkara; Claudia Karakashian; Benjamin Peppers; Andrew J Morris; Mariana N Nikolova-Karakashian
Journal:  J Lipid Res       Date:  2014-07-21       Impact factor: 5.922

4.  Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation.

Authors:  Rajagopal V Sekhar; Sanjeet G Patel; Anuradha P Guthikonda; Marvin Reid; Ashok Balasubramanyam; George E Taffet; Farook Jahoor
Journal:  Am J Clin Nutr       Date:  2011-07-27       Impact factor: 7.045

5.  Age-dependent accumulation of phosphatidylcholine hydroperoxide in the brain and liver of the rat.

Authors:  T Miyazawa; T Suzuki; K Fujimoto
Journal:  Lipids       Date:  1993-09       Impact factor: 1.880

6.  The effects of exogenous glutathione on reduced glutathione level, glutathione peroxidase and glutathione reductase activities of rats with different ages and gender after whole-body Γ-irradiation.

Authors:  Mine Erden Inal; Asiye Akgün; Ahmet Kahraman
Journal:  J Am Aging Assoc       Date:  2003-07

Review 7.  Aging, training and exercise. A review of effects on plasma glutathione and lipid peroxides.

Authors:  M Kretzschmar; D Müller
Journal:  Sports Med       Date:  1993-03       Impact factor: 11.136

8.  Effects of ageing on the content in sulfur-containing amino acids in rat brain.

Authors:  M S Benedetti; A Russo; P Marrari; P Dostert
Journal:  J Neural Transm Gen Sect       Date:  1991

9.  Age-related changes in the antioxidant screen of the distal lung in mice.

Authors:  S Teramoto; Y Fukuchi; Y Uejima; K Teramoto; H Ito; H Orimo
Journal:  Lung       Date:  1994       Impact factor: 2.584

10.  (R)-alpha-lipoic acid reverses the age-related loss in GSH redox status in post-mitotic tissues: evidence for increased cysteine requirement for GSH synthesis.

Authors:  Jung H Suh; Hong Wang; Rui-Ming Liu; JianKang Liu; Tory M Hagen
Journal:  Arch Biochem Biophys       Date:  2004-03-01       Impact factor: 4.013
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