| Literature DB >> 3669186 |
M Abozeid1, K P Juenemann, J A Luo, T F Lue, T S Yen, E A Tanagho.
Abstract
To investigate the effect of chronic papaverine treatment, seven monkeys underwent repeated intracavernous injections for one year. One monkey died after 56 injections; the others received a total of 100 each. The strength and duration of erection were recorded after each injection, and the erectile tissue was examined histologically at the end of the study. Over the long term, papaverine maintains its erection-inducing capability, but it does cause pathologic changes in the erectile tissue: minimal to marked fibrosis at the injection site and hypertrophy of smooth muscle in the non-injected area of the corpus.Entities:
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Year: 1987 PMID： 3669186 DOI： 10.1016/s0022-5347(17)43581-6
Source DB: PubMed Journal: J Urol ISSN： 0022-5347 Impact factor: 7.450