Literature DB >> 3666434

Tests of linkage and heterogeneity in Mendelian diseases using identity by descent scores.

A Chakravarti1, J A Badner, C C Li.   

Abstract

When linkage between a recessive Mendelian disease and specific candidate genes is investigated, identity by descent scores in affected sib pairs may be used for tests of linkage and heterogeneity. Statistical tests for performing this analysis are presented. The efficiency and statistical power of the method are also investigated using computer simulations.

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Year:  1987        PMID： 3666434     DOI： 10.1002/gepi.1370040404

Source DB:  PubMed          Journal:  Genet Epidemiol        ISSN： 0741-0395            Impact factor:   2.135


  5 in total

1.  Sampling strategies for linkage studies.

Authors:  L R Goldin; M M Martinez; E S Gershon
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  1991       Impact factor: 5.270

Review 2.  Current perspectives on the genetics of unipolar depression.

Authors:  S O Moldin; T Reich; J P Rice
Journal:  Behav Genet       Date:  1991-05       Impact factor: 2.805

3.  Sample-size guidelines for linkage analysis of a dominant locus for a quantitative trait by the method of lod scores.

Authors:  M Boehnke
Journal:  Am J Hum Genet       Date:  1990-08       Impact factor: 11.025

4.  Assessing the statistical power to detect linkage in a sample of 51 bipolar affective disorder pedigrees.

Authors:  L C Lim; N Craddock; M Owen; P Sham; M M Nöthen; J Körner; M Rietschel; R Fimmer; P Propping; P McGuffin; R Murray; M Gill
Journal:  Behav Genet       Date:  1996-03       Impact factor: 2.805

5.  The detection of linkage and heterogeneity in nuclear families for complex disorders: one versus two marker loci.

Authors:  M M Martinez; L R Goldin
Journal:  Am J Hum Genet       Date:  1989-04       Impact factor: 11.025
  5 in total

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