Literature DB >> 3665855

Mesovarian leiomyomas in the rat.

C Gopinath1, W A Gibson.   

Abstract

Prolonged treatment with two chemically distinct beta-stimulants, Salbutamol and Terbutaline, resulted in mesovarian leiomyomas in Sprague-Dawley rats. Development of these tumors induced by Salbutamol was prevented by concurrent administration of the beta-blocker Propranolol. Mesovarian leiomyomas induced by Salbutomol did not show any regression or progression during a 44-week postdosing recovery period. This report also gives the first recorded incidence of spontaneous mesovarian leiomyomas in the rat.

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Year:  1987        PMID： 3665855      PMCID： PMC1474549          DOI： 10.1289/ehp.8773107

Source DB:  PubMed          Journal:  Environ Health Perspect        ISSN： 0091-6765            Impact factor:   9.031


  4 in total

1.  Mesovarial leiomyomas in rats in a chronic toxicity study of mesuprine hydrochloride.

Authors:  L W Nelson; W A Kelly; J H Weikel
Journal:  Toxicol Appl Pharmacol       Date:  1972-12       Impact factor: 4.219

2.  Leiomyoma of the ovary: report of five cases and review of the literature.

Authors:  H Fallahzadeh; M B Dockerty; R A Lee
Journal:  Am J Obstet Gynecol       Date:  1972-06-01       Impact factor: 8.661

3.  Beta-adrenoceptor stimulants and mesovarian leiomyomas in the rat.

Authors:  D Jack; D Poynter; N W Spurling
Journal:  Toxicology       Date:  1983 Jul-Aug       Impact factor: 4.221

4.  Toxicology of mabuterol.

Authors:  K Amemiya; M Kudoh; H Suzuki; K Saga; K Hosaka
Journal:  Arzneimittelforschung       Date:  1984
  4 in total
  5 in total

Review 1.  Nonproliferative and proliferative lesions of the rat and mouse female reproductive system.

Authors:  Darlene Dixon; Roger Alison; Ute Bach; Karyn Colman; George L Foley; Johannes H Harleman; Richard Haworth; Ronald Herbert; Anke Heuser; Gerald Long; Michael Mirsky; Karen Regan; Eric Van Esch; F Russell Westwood; Justin Vidal; Midori Yoshida
Journal:  J Toxicol Pathol       Date:  2014       Impact factor: 1.628

2.  Rodent model of reproductive tract leiomyomata. Clinical and pathological features.

Authors:  J I Everitt; D C Wolf; S R Howe; T L Goldsworthy; C Walker
Journal:  Am J Pathol       Date:  1995-06       Impact factor: 4.307

3.  Anti-inflammatory and antinociceptive effects of salbutamol on acute and chronic models of inflammation in rats: involvement of an antioxidant mechanism.

Authors:  Hulya Uzkeser; Elif Cadirci; Zekai Halici; Fehmi Odabasoglu; Beyzagul Polat; Tugba Nurcan Yuksel; Seda Ozaltin; Fadime Atalay
Journal:  Mediators Inflamm       Date:  2012-05-14       Impact factor: 4.711

4.  The fifth plot of the Carcinogenic Potency Database: results of animal bioassays published in the general literature through 1988 and by the National Toxicology Program through 1989.

Authors:  L S Gold; N B Manley; T H Slone; G B Garfinkel; L Rohrbach; B N Ames
Journal:  Environ Health Perspect       Date:  1993-04       Impact factor: 9.031

Review 5.  Proliferative and non-proliferative lesions of the rat and mouse soft tissue, skeletal muscle and mesothelium.

Authors:  Peter Greaves; Luc Chouinard; Heinrich Ernst; Lars Mecklenburg; Ingrid M Pruimboom-Brees; Matthias Rinke; Susanne Rittinghausen; Stéphane Thibault; Jasmin Von Erichsen; Toshinori Yoshida
Journal:  J Toxicol Pathol       Date:  2013       Impact factor: 1.628
  5 in total

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