Literature DB >> 3664638

A genetic linkage map of the human genome.

H Donis-Keller1, P Green, C Helms, S Cartinhour, B Weiffenbach, K Stephens, T P Keith, D W Bowden, D R Smith, E S Lander.   

Abstract

We report the construction of a linkage map of the human genome, based on the pattern of inheritance of 403 polymorphic loci, including 393 RFLPs, in a panel of DNAs from 21 three-generation families. By a combination of mathematical linkage analysis and physical localization of selected clones, it was possible to arrange these loci into linkage groups representing 23 human chromosomes. We estimate that the linkage map is detectably linked to at least 95% of the DNA in the human genome.

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Year:  1987        PMID： 3664638     DOI： 10.1016/0092-8674(87)90158-9

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  195 in total

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5.  Framework multipoint map of the long arm of human chromosome 4 and telomeric localization of the gene for FSHD.

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10.  Type 2 NF1 deletions are highly unusual by virtue of the absence of nonallelic homologous recombination hotspots and an apparent preference for female mitotic recombination.

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