Literature DB >> 3662822

Urinary excretion of acrylonitrile and its metabolites in rats.

G Müller1, C Verkoyen, N Soton, K Norpoth.   

Abstract

Quantitative analysis of the dose-dependent urinary excretion of acrylonitrile and its metabolites was carried out in male Wistar rats following inhalation exposure of the animals to 1, 5, 10, 50 and 100 ppm acrylonitrile for 8 h. Quantitative analysis of acrylonitrile in urine was performed by gas chromatography. The urinary metabolites cyanoethyl mercapturic acid, S-carboxymethyl cysteine and hydroxyethyl mercapturic acid were measured by a modified amino acid analysis, and thiodiglycolic acid by GC-MS. The excretion pattern of the compound and its metabolites was dependent on the exposure level; it is concluded that urinary determination of the unmetabolized acrylonitrile and two of its metabolites, cyanoethyl mercapturic acid and thioglycolic acid, may be useful for biological monitoring of industrial exposure.

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Year:  1987        PMID： 3662822     DOI： 10.1007/bf00302391

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  13 in total

1.  [The proof of acrylnitrile exposure: detoxication of acrylnitrile by coupling with D-glucuronic acid].

Authors:  P Hoffmann; D Kleine; E Franzen
Journal:  Z Gesamte Hyg       Date:  1976-05

2.  In vitro metabolism of acrylonitrile to 2-cyanoethylene oxide, reaction with glutathione, and irreversible binding to proteins and nucleic acids.

Authors:  F P Guengerich; L E Geiger; L L Hogy; P L Wright
Journal:  Cancer Res       Date:  1981-12       Impact factor: 12.701

3.  Experimental pharmacokinetics and toxicology of acrylonitrile.

Authors:  H Peter; H M Bolt
Journal:  G Ital Med Lav       Date:  1984 May-Jul

4.  Structural considerations in the metabolism of nitriles to cyanide in vivo.

Authors:  E H Silver; S H Kuttab; T Hasan; M Hassan
Journal:  Drug Metab Dispos       Date:  1982 Sep-Oct       Impact factor: 3.922

5.  Formation of mercapturic acids from acrylonitrile, crotononitrile, and cinnamonitrile by direct conjugation and via an intermediate oxidation process.

Authors:  P J van Bladeren; L P Delbressine; J J Hoogeterp; A H Beaumont; D D Breimer; F Seutter-Berlage; A van der Gen
Journal:  Drug Metab Dispos       Date:  1981 May-Jun       Impact factor: 3.922

6.  Health effects of acrylonitrile in acrylic fibre factories.

Authors:  H Sakurai; M Onodera; T Utsunomiya; H Minakuchi; H Iwai; H Matsumura
Journal:  Br J Ind Med       Date:  1978-08

7.  Identification of the major urinary metabolites of acrylonitrile in the rat.

Authors:  P W Langvardt; C L Putzig; W H Braun; J D Young
Journal:  J Toxicol Environ Health       Date:  1980-03

8.  Identification of two urinary metabolites of rats treated with acrylonitrile; influence of several inhibitors on the mutagenicity of those urines.

Authors:  M Lambotte-Vandepaer; M Duverger-Van Bogaert; C de Meester; B Rollmann; F Poncelet; M Mercier
Journal:  Toxicol Lett       Date:  1981-02       Impact factor: 4.372

9.  Effect of several factors on the liver extract mediated mutagenicity of acrylonitrile and identification of four new in vitro metabolites.

Authors:  M Duverger-Van Bogaert; M Lambotte-Vandepaer; C de Meester; B Rollmann; F Poncelet; M Mercier
Journal:  Toxicol Lett       Date:  1981-02       Impact factor: 4.372

10.  New findings on acrylonitrile metabolism.

Authors:  J Kopecký; D Zachardová; I Gut
Journal:  Czech Med       Date:  1980
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  1 in total

Review 1.  N-acetyl-S-(2-hydroxyethyl)-L-cysteine as a potential tool in biological monitoring studies? A critical evaluation of possibilities and limitations.

Authors:  N P Vermeulen; J de Jong; E J van Bergen; R T van Welie
Journal:  Arch Toxicol       Date:  1989       Impact factor: 5.153
  1 in total

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