Effects of antihypertensive drugs on plasma lipids.

Among the risk factors associated with atherosclerotic coronary artery diseases, systemic hypertension and disorders of plasma lipoproteins and apoproteins are very important. Blood lipid changes have been reported with a number of antihypertensive drugs and may conceivably reduce the coronary artery disease-protective benefits of blood pressure reduction. The prevalence of various types of hyperlipoproteinemia among Japanese is discussed, with special reference to the frequency of atherosclerotic vascular diseases. Data concerning the effects of commonly prescribed antihypertensive drugs on blood lipids and apolipoproteins are reported.