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Literature DB >> 2257855

Effect of ketanserin tartrate on HMG CoA reductase and LDL receptor activity in cultured human skin fibroblasts.

Abstract

In man ketanserin tartrate reduces plasma LDL cholesterol. To clarify the mechanism of this effect the effect of ketanserin on 3-hydroxy-3-methylglutaryl (HMG) CoA reductase and LDL receptor activity in cultured human skin fibroblasts has been examined. After incubation with ketanserin for 14 h HMG CoA reductase activity was decreased in a dose-dependent manner up to 300 ng/ml (550 nM) without changing the free cholesterol content in the cells. Ketanserin increased specific binding and specific internalization of 125I-LDL dose-dependently. There was a significant inverse relationship between the percentage changes in HMG CoA reductase and LDL receptor activity. It appears that ketanserin induces up-regulation of LDL receptor activity by direct suppression of HMG CoA reductase, and this may be one mechanism by which plasma LDL-cholesterol is reduced by ketanserin.

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Year: 1990 PMID： 2257855 DOI： 10.1007/bf00315099

Source DB: PubMed Journal: Eur J Clin Pharmacol ISSN： 0031-6970 Impact factor: 2.953

24 in total

Review 1. Cholesterol in the prediction of atherosclerotic disease. New perspectives based on the Framingham study.

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2. Serum cholesterol during ketanserin and propranolol administration in hypertensive patients.

Authors: P Lijnen; R Fagard; J Staessen; V Blaton; P Hollez; G Rorive; A Amery
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3. Effects of treatment on morbidity in hypertension. 3. Influence of age, diastolic pressure, and prior cardiovascular disease; further analysis of side effects.

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4. Effects of treatment on morbidity in hypertension. II. Results in patients with diastolic blood pressure averaging 90 through 114 mm Hg.

Authors:
Journal: JAMA Date: 1970-08-17 Impact factor: 56.272

5. Receptor binding profile of R 41 468, a novel antagonist at 5-HT2 receptors.

Authors: J E Leysen; F Awouters; L Kennis; P M Laduron; J Vandenberk; P A Janssen
Journal: Life Sci Date: 1981-03-02 Impact factor: 5.037

6. Modulation of 3-hydroxy-3-methylglutaryl-CoA reductase and of acyl-CoA--cholesterol acyltransferase by the transfer of non-esterified cholesterol to rat liver microsomal vesicles.

Authors: K A Mitropoulos; S Venkatesan; B E Reeves; S Balasubramaniam
Journal: Biochem J Date: 1981-01-15 Impact factor: 3.857

7. Iodination of proteins, glycoproteins, and peptides using a solid-phase oxidizing agent, 1,3,4,6-tetrachloro-3 alpha,6 alpha-diphenyl glycoluril (Iodogen).

Authors: P R Salacinski; C McLean; J E Sykes; V V Clement-Jones; P J Lowry
Journal: Anal Biochem Date: 1981-10 Impact factor: 3.365

2. Ketanserin, an antidepressant, exerts its antileishmanial action via inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) enzyme of Leishmania donovani.

Authors: Sushma Singh; Neeradi Dinesh; Preet Kamal Kaur; Baigadda Shamiulla
Journal: Parasitol Res Date: 2014-04-12 Impact factor: 2.289

2 in total

Effect of ketanserin tartrate on HMG CoA reductase and LDL receptor activity in cultured human skin fibroblasts.

Review 1. Cholesterol in the prediction of atherosclerotic disease. New perspectives based on the Framingham study.

2. Serum cholesterol during ketanserin and propranolol administration in hypertensive patients.

3. Effects of treatment on morbidity in hypertension. 3. Influence of age, diastolic pressure, and prior cardiovascular disease; further analysis of side effects.

4. Effects of treatment on morbidity in hypertension. II. Results in patients with diastolic blood pressure averaging 90 through 114 mm Hg.

5. Receptor binding profile of R 41 468, a novel antagonist at 5-HT2 receptors.

6. Modulation of 3-hydroxy-3-methylglutaryl-CoA reductase and of acyl-CoA--cholesterol acyltransferase by the transfer of non-esterified cholesterol to rat liver microsomal vesicles.

7. Iodination of proteins, glycoproteins, and peptides using a solid-phase oxidizing agent, 1,3,4,6-tetrachloro-3 alpha,6 alpha-diphenyl glycoluril (Iodogen).

8. Effects of doxazosin on lipids, lipoprotein lipases, and cholesterol synthesis in the golden hamster.

Review 9. Receptor-mediated endocytosis: insights from the lipoprotein receptor system.

10. Effects of antihypertensive drugs on plasma lipids.

1. Effects of beta-blockers on HMG CoA reductase and LDL receptor activity in cultured human skin fibroblasts.

2. Ketanserin, an antidepressant, exerts its antileishmanial action via inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) enzyme of Leishmania donovani.