Literature DB >> 3651529

Diminished mitogen-induced calcium uptake by lymphocytes from Alzheimer patients.

G E Gibson1, P Nielsen, K A Sherman, J P Blass.   

Abstract

Recent studies demonstrate diminished calcium uptake by cultured skin fibroblasts from Alzheimer patients. To determine if altered calcium homeostasis is also present in tissue taken from Alzheimer patients, calcium homeostasis was assessed in mitogen-stimulated lymphocytes. Calcium uptake by lymphocytes from Alzheimer patients was 10%-15% lower (p less than 0.002) than that of lymphocytes from age-matched controls. However, neither superficially bound nor total calcium was altered by Alzheimer's disease. These small differences in uptake may reflect larger differences in cytosolic calcium, in later calcium-mediated events, or in the response of particular subsets of lymphocytes. Their biological significance remains to be determined.

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Year:  1987        PMID： 3651529     DOI： 10.1016/0006-3223(87)90050-3

Source DB:  PubMed          Journal:  Biol Psychiatry        ISSN： 0006-3223            Impact factor:   13.382


  7 in total

1.  Deficits in the mitochondrial enzyme α-ketoglutarate dehydrogenase lead to Alzheimer's disease-like calcium dysregulation.

Authors:  Gary E Gibson; Huan-Lian Chen; Hui Xu; Linghua Qiu; Zuoshang Xu; Travis T Denton; Qingli Shi
Journal:  Neurobiol Aging       Date:  2011-12-14       Impact factor: 4.673

Review 2.  Interactions of Mitochondria/Metabolism and Calcium Regulation in Alzheimer's Disease: A Calcinist Point of View.

Authors:  Gary E Gibson; Ankita Thakkar
Journal:  Neurochem Res       Date:  2017-02-08       Impact factor: 3.996

Review 3.  Systemic and brain metabolic dysfunction as a new paradigm for approaching Alzheimer's dementia.

Authors:  Vincenzo Giordano; Gianfranco Peluso; Maurizio Iannuccelli; Paola Benatti; Raffaella Nicolai; Menotti Calvani
Journal:  Neurochem Res       Date:  2006-08-17       Impact factor: 3.996

Review 4.  Mitochondria and cell bioenergetics: increasingly recognized components and a possible etiologic cause of Alzheimer's disease.

Authors:  Russell H Swerdlow
Journal:  Antioxid Redox Signal       Date:  2011-09-15       Impact factor: 8.401

5.  Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration.

Authors:  K Saito; J S Elce; J E Hamos; R A Nixon
Journal:  Proc Natl Acad Sci U S A       Date:  1993-04-01       Impact factor: 11.205

6.  Potassium channel dysfunction in fibroblasts identifies patients with Alzheimer disease.

Authors:  R Etcheberrigaray; E Ito; K Oka; B Tofel-Grehl; G E Gibson; D L Alkon
Journal:  Proc Natl Acad Sci U S A       Date:  1993-09-01       Impact factor: 11.205

7.  Studies of neuroimmune markers in Alzheimer's disease.

Authors:  V K Singh
Journal:  Mol Neurobiol       Date:  1994 Aug-Dec       Impact factor: 5.590
  7 in total

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