| Literature DB >> 364652 |
M B Yatvin, J N Weinstein, W H Dennis, R Blumenthal.
Abstract
Liposomes can be designed to release an entrapped drug preferentially at temperatures attainable by mild local hyperthermia. In a test system in vitro, protein synthesis by Escherichia coli is inhibited and killing of the cells is enhanced by heating neomycin-containing liposomes to their phase transition temperature to maximize drug release. In the presence of serum the ratio of release at 44 degrees C to that at 37 degrees C can be made greater than 100:1, suggesting possible applications in the treatment of tumors or local infection.Entities:
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Year: 1978 PMID： 364652 DOI： 10.1126/science.364652
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728