Literature DB >> 3631594

MAC of I-653 in rats, including a test of the effect of body temperature and anesthetic duration.

E I Eger, B H Johnson.   

Abstract

The anesthetic potency of a new fluorinated volatile anesthetic, I-653, was tested preliminary to testing its toxic and metabolic characteristics in rats. The minimum alveolar concentration (MAC) of I-653 at 37.9 +/- 0.2 degrees C (mean +/- SD) in eight rats was 5.72 +/- 0.40%. In five rats, we reduced the rectal temperature to 28 degrees C in two steps of 5 degrees C. MAC decreased by 0.238 +/- 0.036% I-653 per degree centigrade decrease in temperature. That is, MAC decreased 42% as temperature decreased 10 degrees C. We restored the temperature to 38 degrees C and redetermined MAC. This value (5.66 +/- 0.75%) did not differ from the average MAC obtained before hypothermia (5.84 +/- 0.36%).

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Year:  1987        PMID： 3631594

Source DB:  PubMed          Journal:  Anesth Analg        ISSN： 0003-2999            Impact factor:   5.108


  15 in total

Review 1.  [Pharmacokinetic-pharmacodynamic models for inhaled anaesthetics].

Authors:  S Kreuer; J Bruhn; W Wilhelm; T Bouillon
Journal:  Anaesthesist       Date:  2007-06       Impact factor: 1.041

2.  Hypothermia decreases ethanol MAC in rats.

Authors:  Albert Won; Irene Oh; Robert Brosnan; Edmond I Eger; James M Sonner
Journal:  J Anesth       Date:  2006       Impact factor: 2.078

3.  Unintended perioperative hypothermia.

Authors:  Stuart R Hart; Brianne Bordes; Jennifer Hart; Daniel Corsino; Donald Harmon
Journal:  Ochsner J       Date:  2011

4.  Distinct long-term neurocognitive outcomes after equipotent sevoflurane or isoflurane anaesthesia in immature rats.

Authors:  T M Ramage; F L Chang; J Shih; R S Alvi; G R Quitoriano; V Rau; K C Barbour; S A Elphick; C L Kong; N K Tantoco; D Ben-Tzur; H Kang; M S McCreery; P Huang; A Park; J Uy; M J Rossi; C Zhao; R T Di Geronimo; G Stratmann; J W Sall
Journal:  Br J Anaesth       Date:  2013-04-16       Impact factor: 9.166

5.  The effects of temperature on the interactions between volatile general anaesthetics and a neuronal nicotinic acetylcholine receptor.

Authors:  R Dickinson; W R Lieb; N P Franks
Journal:  Br J Pharmacol       Date:  1995-12       Impact factor: 8.739

Review 6.  Desflurane. A review of its pharmacodynamic and pharmacokinetic properties and its efficacy in general anaesthesia.

Authors:  S S Patel; K L Goa
Journal:  Drugs       Date:  1995-10       Impact factor: 9.546

Review 7.  Is a new paradigm needed to explain how inhaled anesthetics produce immobility?

Authors:  Edmond I Eger; Douglas E Raines; Steven L Shafer; Hugh C Hemmings; James M Sonner
Journal:  Anesth Analg       Date:  2008-09       Impact factor: 5.108

8.  Increases in spinal cerebrospinal fluid potassium concentration do not increase isoflurane minimum alveolar concentration in rats.

Authors:  Dimitry Shnayderman; Michael J Laster; Edmond I Eger; Irene Oh; Yi Zhang; Steven L Jinks; Joseph F Antognini; Douglas E Raines
Journal:  Anesth Analg       Date:  2008-09       Impact factor: 5.108

Review 9.  Desflurane clinical pharmacokinetics and pharmacodynamics.

Authors:  J E Caldwell
Journal:  Clin Pharmacokinet       Date:  1994-07       Impact factor: 6.447

10.  Paradox of age: older patients receive higher age-adjusted minimum alveolar concentration fractions of volatile anaesthetics yet display higher bispectral index values.

Authors:  Katherine Ni; Mary Cooter; Dhanesh K Gupta; Jake Thomas; Thomas J Hopkins; Timothy E Miller; Michael L James; Miklos D Kertai; Miles Berger
Journal:  Br J Anaesth       Date:  2019-07-03       Impact factor: 9.166
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