| Literature DB >> 36273105 |
Sonja I Berndt1, Joseph Vijai2, Yolanda Benavente3,4, Nicola J Camp5, Alexandra Nieters6, Zhaoming Wang7,8, Karin E Smedby9,10, Geffen Kleinstern11, Henrik Hjalgrim12,13,14,15, Caroline Besson16,17, Christine F Skibola18, Lindsay M Morton19, Angela R Brooks-Wilson20,21, Lauren R Teras22, Charles Breeze19, Joshua Arias19, Hans-Olov Adami23,24,25, Demetrius Albanes19, Kenneth C Anderson26, Stephen M Ansell27, Bryan Bassig19, Nikolaus Becker28, Parveen Bhatti29, Brenda M Birmann30, Paolo Boffetta31,32, Paige M Bracci33, Paul Brennan34, Elizabeth E Brown35, Laurie Burdett36, Lisa A Cannon-Albright5,37, Ellen T Chang33,38, Brian C H Chiu39, Charles C Chung19, Jacqueline Clavel40,41, Pierluigi Cocco42, Graham Colditz43, Lucia Conde44, David V Conti45, David G Cox46, Karen Curtin5, Delphine Casabonne3,4, Immaculata De Vivo24,30, W Ryan Diver22, Ahmet Dogan47, Christopher K Edlund45, Lenka Foretova48, Joseph F Fraumeni19, Attilio Gabbas49, Hervé Ghesquières50,51, Graham G Giles52,53,54, Sally Glaser55,56, Martha Glenn5, Bengt Glimelius57, Jian Gu58, Thomas M Habermann27, Christopher A Haiman45, Corinne Haioun59, Jonathan N Hofmann19, Theodore R Holford60, Elizabeth A Holly33, Amy Hutchinson36, Aalin Izhar2, Rebecca D Jackson61, Ruth F Jarrett62, Rudolph Kaaks28, Eleanor Kane63, Laurence N Kolonel64, Yinfei Kong65, Peter Kraft24,66, Anne Kricker67, Annette Lake62, Qing Lan19, Charles Lawrence68, Dalin Li69, Mark Liebow27, Brian K Link70, Corrado Magnani71, Marc Maynadie72, James McKay34, Mads Melbye13,73,74,75, Lucia Miligi76, Roger L Milne52,53,54, Thierry J Molina77, Alain Monnereau40,78, Rebecca Montalvan68, Kari E North79,80, Anne J Novak27, Kenan Onel81, Mark P Purdue19, Kristin A Rand45, Elio Riboli82, Jacques Riby83,84, Eve Roman63, Gilles Salles2, Douglas W Sborov5, Richard K Severson85, Tait D Shanafelt86, Martyn T Smith84, Alexandra Smith63, Kevin W Song87,88, Lei Song89, Melissa C Southey52,54,90, John J Spinelli91,92, Anthony Staines93, Deborah Stephens5, Heather J Sutherland87,88, Kaitlyn Tkachuk2, Carrie A Thompson27, Hervé Tilly94, Lesley F Tinker29, Ruth C Travis95, Jenny Turner96,97, Celine M Vachon98, Claire M Vajdic99, Anke Van Den Berg100, David J Van Den Berg45, Roel C H Vermeulen101,102, Paolo Vineis103,104, Sophia S Wang105, Elisabete Weiderpass34, George J Weiner70, Stephanie Weinstein19, Nicole Wong Doo106, Yuanqing Ye58, Meredith Yeager19,36, Kai Yu19, Anne Zeleniuch-Jacquotte107,108,109, Yawei Zhang110, Tongzhang Zheng111, Elad Ziv112, Joshua Sampson19, Nilanjan Chatterjee19,113,114, Kenneth Offit2, Wendy Cozen115, Xifeng Wu58, James R Cerhan116, Stephen J Chanock19, Susan L Slager116, Nathaniel Rothman19.
Abstract
Lymphoma risk is elevated for relatives with common non-Hodgkin lymphoma (NHL) subtypes, suggesting shared genetic susceptibility across subtypes. To evaluate the extent of mutual heritability among NHL subtypes and discover novel loci shared among subtypes, we analyzed data from eight genome-wide association studies within the InterLymph Consortium, including 10,629 cases and 9505 controls. We utilized Association analysis based on SubSETs (ASSET) to discover loci for subsets of NHL subtypes and evaluated shared heritability across the genome using Genome-wide Complex Trait Analysis (GCTA) and polygenic risk scores. We discovered 17 genome-wide significant loci (P < 5 × 10-8) for subsets of NHL subtypes, including a novel locus at 10q23.33 (HHEX) (P = 3.27 × 10-9). Most subset associations were driven primarily by only one subtype. Genome-wide genetic correlations between pairs of subtypes varied broadly from 0.20 to 0.86, suggesting substantial heterogeneity in the extent of shared heritability among subtypes. Polygenic risk score analyses of established loci for different lymphoid malignancies identified strong associations with some NHL subtypes (P < 5 × 10-8), but weak or null associations with others. Although our analyses suggest partially shared heritability and biological pathways, they reveal substantial heterogeneity among NHL subtypes with each having its own distinct germline genetic architecture.Entities:
Year: 2022 PMID： 36273105 DOI： 10.1038/s41375-022-01711-0
Source DB: PubMed Journal: Leukemia ISSN： 0887-6924 Impact factor: 12.883