Tórur Sjúrðarson1,2, Jacob Bejder2, Andreas Breenfeldt Andersen2, Thomas C Bonne2, Kasper Kyhl3, Martin Thomassen2, Júlia Prats2, Noomi Oddmarsdóttir Gregersen4, May-Britt Skoradal1, Pál Weihe1,5, Nikolai B Nordsborg2, Magni Mohr6,7. 1. Center of Health Science, Faculty of Health, University of the Faroe Islands, Tórshavn, Faroe Islands. 2. Department of Nutrition, Exercise and Sports (NEXS), University of Copenhagen, Copenhagen, Denmark. 3. Department of Cardiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark. 4. FarGen, The Genetic Biobank of the Faroe Islands, Tórshavn, Faroe Islands. 5. Department of Occupational Medicine and Public Health, The Faroese Hospital System, Tórshavn, Faroe Islands. 6. Center of Health Science, Faculty of Health, University of the Faroe Islands, Tórshavn, Faroe Islands. magnim@setur.fo. 7. Department of Sports Science and Clinical Biomechanics, Faculty of Health Sciences, SDU Sport and Health Sciences Cluster (SHSC), University of Southern Denmark, Odense, Denmark. magnim@setur.fo.
Abstract
PURPOSE: Angiotensin-converting enzyme (ACE) inhibitor treatment is widely applied, but the fact that plasma ACE activity is a potential determinant of training-induced local muscular adaptability is often neglected. Thus, we investigated the hypothesis that ACE inhibition modulates the response to systematic aerobic exercise training on leg and arm muscular adaptations. METHODS: Healthy, untrained, middle-aged participants (40 ± 7 yrs) completed a randomized, double-blinded, placebo-controlled trial. Participants were randomized to placebo (PLA: CaCO3) or ACE inhibitor (ACEi: enalapril) for 8 weeks and completed a supervised, high-intensity exercise training program. Muscular characteristics in the leg and arm were extensively evaluated pre and post-intervention. RESULTS: Forty-eight participants (nACEi = 23, nPLA = 25) completed the trial. Exercise training compliance was above 99%. After training, citrate synthase, 3-hydroxyacyl-CoA dehydrogenase and phosphofructokinase maximal activity were increased in m. vastus lateralis in both groups (all P < 0.05) without statistical differences between them (all time × treatment P > 0.05). In m. deltoideus, citrate synthase maximal activity was upregulated to a greater extent (time × treatment P < 0.05) in PLA (51 [33;69] %) than in ACEi (28 [13;43] %), but the change in 3-hydroxyacyl-CoA dehydrogenase and phosphofructokinase maximal activity was similar between groups. Finally, the training-induced changes in the platelet endothelial cell adhesion molecule-1 protein abundance, a marker of capillary density, were similar in both groups in m. vastus lateralis and m. deltoideus. CONCLUSION: Eight weeks of high-intensity whole-body exercise training improves markers of skeletal muscle mitochondrial oxidative capacity, glycolytic capacity and angiogenesis, with no overall effect of pharmacological ACE inhibition in healthy adults.
PURPOSE: Angiotensin-converting enzyme (ACE) inhibitor treatment is widely applied, but the fact that plasma ACE activity is a potential determinant of training-induced local muscular adaptability is often neglected. Thus, we investigated the hypothesis that ACE inhibition modulates the response to systematic aerobic exercise training on leg and arm muscular adaptations. METHODS: Healthy, untrained, middle-aged participants (40 ± 7 yrs) completed a randomized, double-blinded, placebo-controlled trial. Participants were randomized to placebo (PLA: CaCO3) or ACE inhibitor (ACEi: enalapril) for 8 weeks and completed a supervised, high-intensity exercise training program. Muscular characteristics in the leg and arm were extensively evaluated pre and post-intervention. RESULTS: Forty-eight participants (nACEi = 23, nPLA = 25) completed the trial. Exercise training compliance was above 99%. After training, citrate synthase, 3-hydroxyacyl-CoA dehydrogenase and phosphofructokinase maximal activity were increased in m. vastus lateralis in both groups (all P < 0.05) without statistical differences between them (all time × treatment P > 0.05). In m. deltoideus, citrate synthase maximal activity was upregulated to a greater extent (time × treatment P < 0.05) in PLA (51 [33;69] %) than in ACEi (28 [13;43] %), but the change in 3-hydroxyacyl-CoA dehydrogenase and phosphofructokinase maximal activity was similar between groups. Finally, the training-induced changes in the platelet endothelial cell adhesion molecule-1 protein abundance, a marker of capillary density, were similar in both groups in m. vastus lateralis and m. deltoideus. CONCLUSION: Eight weeks of high-intensity whole-body exercise training improves markers of skeletal muscle mitochondrial oxidative capacity, glycolytic capacity and angiogenesis, with no overall effect of pharmacological ACE inhibition in healthy adults.
Authors: H Hruskovicová; D Dzurenková; M Selingerová; B Bohus; B Timkanicová; L Kovács Journal: J Sports Med Phys Fitness Date: 2006-09 Impact factor: 1.637
Authors: Mari-Carmen Gomez-Cabrera; Elena Domenech; Marco Romagnoli; Alessandro Arduini; Consuelo Borras; Federico V Pallardo; Juan Sastre; Jose Viña Journal: Am J Clin Nutr Date: 2008-01 Impact factor: 7.045