BACKGROUND: Serum angiotensin-converting enzyme (ACE) activity has been related to sarcoidosis and other granulomatous diseases. It has been demonstrated that serum ACE activity is influenced by ACE gene I/D polymorphism. The aim of this study was to establish ACE activity reference values according to genotype in a Spanish population to improve diagnostic sensitivity and treatment monitoring in sarcoidosis patients. METHODS: A sample population of 150 blood donors was included in the study. Serum ACE activity and genotype were determined and the reference intervals, defined as the 95% central range of the population (2.5th-97.5th percentiles) were obtained for all three genotypes (DD, DI, II) and for the entire sample. RESULTS: Genotype frequencies were 37% DD (n=54), 43% DI (n=63), and 20% II (n=30). Individuals with DD genotype showed the highest ACE activity (mean 39.0 U/L, SD 13.6), ID genotype showed intermediate levels (mean 29.5 U/L, SD 10.2) and II genotype lowest levels (mean 19.1 U/L, SD 4.9). ACE activity differed significantly between these groups: F (2144)=33.15, p<0.05. The corresponding reference intervals for ACE activity were 13.3-63.9 U/L in the overall sample, 12.3-65.6 U/L in genotype DD, 9.5-49.5 U/L in DI and 9.6-28.7 in II. CONCLUSIONS: The preliminary reference values for ACE activity in healthy Spanish individuals according to I/D polymorphism are presented. Significant differences in these values were found between the genotype groups.
BACKGROUND: Serum angiotensin-converting enzyme (ACE) activity has been related to sarcoidosis and other granulomatous diseases. It has been demonstrated that serum ACE activity is influenced by ACE gene I/D polymorphism. The aim of this study was to establish ACE activity reference values according to genotype in a Spanish population to improve diagnostic sensitivity and treatment monitoring in sarcoidosispatients. METHODS: A sample population of 150 blood donors was included in the study. Serum ACE activity and genotype were determined and the reference intervals, defined as the 95% central range of the population (2.5th-97.5th percentiles) were obtained for all three genotypes (DD, DI, II) and for the entire sample. RESULTS: Genotype frequencies were 37% DD (n=54), 43% DI (n=63), and 20% II (n=30). Individuals with DD genotype showed the highest ACE activity (mean 39.0 U/L, SD 13.6), ID genotype showed intermediate levels (mean 29.5 U/L, SD 10.2) and II genotype lowest levels (mean 19.1 U/L, SD 4.9). ACE activity differed significantly between these groups: F (2144)=33.15, p<0.05. The corresponding reference intervals for ACE activity were 13.3-63.9 U/L in the overall sample, 12.3-65.6 U/L in genotype DD, 9.5-49.5 U/L in DI and 9.6-28.7 in II. CONCLUSIONS: The preliminary reference values for ACE activity in healthy Spanish individuals according to I/D polymorphism are presented. Significant differences in these values were found between the genotype groups.
Authors: Lyubov E Salnikova; Tamara V Smelaya; Irina N Vesnina; Arkadiy M Golubev; Viktor V Moroz Journal: Inflammation Date: 2014-04 Impact factor: 4.092
Authors: Tórur Sjúrðarson; Jacob Bejder; Andreas Breenfeldt Andersen; Thomas C Bonne; Kasper Kyhl; Martin Thomassen; Júlia Prats; Noomi Oddmarsdóttir Gregersen; May-Britt Skoradal; Pál Weihe; Nikolai B Nordsborg; Magni Mohr Journal: Eur J Appl Physiol Date: 2022-10-22 Impact factor: 3.346
Authors: Robert Kieszko; Paweł Krawczyk; Tomasz Powrózek; Aneta Szudy-Szczyrek; Michał Szczyrek; Iwona Homa; Jadwiga Daniluk; Janusz Milanowski Journal: Arch Med Sci Date: 2015-04-28 Impact factor: 3.318