| Literature DB >> 36266362 |
Andrew Clark1, Subhadip Ghatak1, Poornachander Reddy Guda1, Mohamed S El Masry1, Yi Xuan1,2, Amy Y Sato3,4,5, Teresita Bellido3,4,6,7,8,5, Chandan K Sen9,10.
Abstract
This work rests on our non-viral tissue nanotransfection (TNT) platform to deliver MyoD (TNTMyoD) to injured tissue in vivo. TNTMyoD was performed on skin and successfully induced expression of myogenic factors. TNTMyoD was then used as a therapy 7 days following volumetric muscle loss (VML) of rat tibialis anterior and rescued muscle function. TNTMyoD is promising as VML intervention.Entities:
Year: 2022 PMID: 36266362 PMCID: PMC9585072 DOI: 10.1038/s41536-022-00259-y
Source DB: PubMed Journal: NPJ Regen Med ISSN: 2057-3995