Sri Adila Nurainiwati1, Mochammad Ma'roef2, Dwi Nurwulan Pravitasari1, Probo Yudha Pratama Putra3. 1. Department Dermatology and Venereology, Medical Faculty University of Muhammadiyah Malang, Malang, Indonesia. 2. Department Obstetric and Gynecology, Medical Faculty, University of Muhammadiyah Malang, Malang, Indonesia. 3. Medical Faculty University of Muhammadiyah Malang, Malang, Indonesia.
Abstract
Introduction: Bacterial Vaginosis (BV) is the most common cause of vaginal discharge. However, in some cases, side effects and resistance rates have been reported when antibiotics are administered. This problem has prompted several investigations on the administration of probiotics as an adjunct therapy to treat this infection. Objection: This study aims to conduct a meta-analysis based on evidence to determine the efficacy and safety of probiotic and antibiotic treatments. Methods: The meta-analysis was performed using PRISMA guidelines. The literature review was conducted in December 2020 using PubMed, Science Direct, Cochrane Library, and RevMan V.5.3. Result: The results showed a high and significant cure rate from the analysis of 1006 and 528 samples of probiotics and non-probiotics or control in 16 studies. The recurrence rate was statistically significant with probiotic treatment. Furthermore, neither procedures nor therapy failure showed a significantly lower adverse event rate than the control group. Conclusion: Probiotic shows better results compared to the control group. However, both have the same occurrence of adverse event.
Introduction: Bacterial Vaginosis (BV) is the most common cause of vaginal discharge. However, in some cases, side effects and resistance rates have been reported when antibiotics are administered. This problem has prompted several investigations on the administration of probiotics as an adjunct therapy to treat this infection. Objection: This study aims to conduct a meta-analysis based on evidence to determine the efficacy and safety of probiotic and antibiotic treatments. Methods: The meta-analysis was performed using PRISMA guidelines. The literature review was conducted in December 2020 using PubMed, Science Direct, Cochrane Library, and RevMan V.5.3. Result: The results showed a high and significant cure rate from the analysis of 1006 and 528 samples of probiotics and non-probiotics or control in 16 studies. The recurrence rate was statistically significant with probiotic treatment. Furthermore, neither procedures nor therapy failure showed a significantly lower adverse event rate than the control group. Conclusion: Probiotic shows better results compared to the control group. However, both have the same occurrence of adverse event.
Authors: Ruben Hummelen; John Changalucha; Nicodemus L Butamanya; Adrian Cook; J Dik F Habbema; Gregor Reid Journal: Int J Gynaecol Obstet Date: 2010-12 Impact factor: 3.561
Authors: Rafael C R Martinez; Sílvio A Franceschini; Maristela C Patta; Silvana M Quintana; Bruna C Gomes; Elaine C P De Martinis; Gregor Reid Journal: Can J Microbiol Date: 2009-02 Impact factor: 2.419
Authors: Marijn C Verwijs; Stephen K Agaba; Alistair C Darby; Janneke H H M van de Wijgert Journal: Am J Obstet Gynecol Date: 2019-08-09 Impact factor: 8.661