Hui Zheng1,2, Nick Walsh3, Olufunmilayo Lesi4, Fuqiang Cui5,6,7. 1. Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China. 2. Department of Laboratorial Science and Technology, School of Public Health, Peking University, Beijing, China. 3. Epidemiology and Preventive Medicine Alfred Hospital, Faculty of Medicine, Monash University, Melbourne, Australia. 4. Department of HIV, Hepatitis and STIs, Global Hepatitis Programme, World Health Organization, Geneva, Switzerland. 5. Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China. cuifuq@126.com. 6. Department of Laboratorial Science and Technology, School of Public Health, Peking University, Beijing, China. cuifuq@126.com. 7. Global Center for Infectious Disease and Policy Research and Global Health and Infectious Diseases Group, Peking University, Beijing, China. cuifuq@126.com.
Abstract
BACKGROUND: We conducted an evaluation on the potential data resources for the elimination of hepatitis B virus (HBV) mother-to-child transmission in China, so as to provide reference for WHO and other countries in the validation of HBV elimination of mother-to-child transmission (EMTCT) in a real-world large country setting. METHODS: We used the indicators set out in WHO Interim guidance for country validation of viral hepatitis elimination as the benchmark to evaluate the availability of data and progress against indicators for the elimination validation in China. We used descriptive analysis to illustrate the status of all indicators and parameters. RESULTS: According to the indicators which are recommended by WHO for HBV EMTCT validation, the national data in China are attainable, though not for HBV DNA testing for the HBsAg-positive mothers and their subsequent management. The remaining challenges for China are to consider how the national serosurvey might be conducted in future in the context of low HBV prevalence among children under 5 years; to collect systematically the programmatic impact data; to strengthen multi-sectoral collaboration among immunization, maternal and child health, hospital services, as well as other stakeholders. CONCLUSION: The available data on HBV EMTCT are sufficient to support the validation of the elimination of HBV mother-to-child transmission in China.
BACKGROUND: We conducted an evaluation on the potential data resources for the elimination of hepatitis B virus (HBV) mother-to-child transmission in China, so as to provide reference for WHO and other countries in the validation of HBV elimination of mother-to-child transmission (EMTCT) in a real-world large country setting. METHODS: We used the indicators set out in WHO Interim guidance for country validation of viral hepatitis elimination as the benchmark to evaluate the availability of data and progress against indicators for the elimination validation in China. We used descriptive analysis to illustrate the status of all indicators and parameters. RESULTS: According to the indicators which are recommended by WHO for HBV EMTCT validation, the national data in China are attainable, though not for HBV DNA testing for the HBsAg-positive mothers and their subsequent management. The remaining challenges for China are to consider how the national serosurvey might be conducted in future in the context of low HBV prevalence among children under 5 years; to collect systematically the programmatic impact data; to strengthen multi-sectoral collaboration among immunization, maternal and child health, hospital services, as well as other stakeholders. CONCLUSION: The available data on HBV EMTCT are sufficient to support the validation of the elimination of HBV mother-to-child transmission in China.
Authors: Zheng Hui; Shevanthi Nayagam; Polin Chan; Wang Fuzhen; Mark Thursz; Yin Zundong; Miao Ning; Sun Xiaojin; Fuqiang Cui; Zhang Guomin; Timothy B Hallett Journal: Bull World Health Organ Date: 2020-10-28 Impact factor: 9.408