Literature DB >> 36255632

Assessing the Effect of Histone Deacetylase Inhibitors on DNA Double-Strand Break Repair by Nonhomologous End Joining.

Oliver H Krämer1, Tamara Diehl1, Wynand P Roos2.   

Abstract

This book chapter describes a plasmid-based reporter method, first described by Bennardo et al. (2008) that we use in our laboratory for determining the activity of the repair of DNA double-strand breaks by nonhomologous end joining. This method can be used to measure the impact of epigenetic modifiers of the histone deacetylase family on this DNA repair pathway by flow cytometry.
© 2023. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  Class I histone deacetylases; Histone deacetylase inhibitors; Nonhomologous end joining

Mesh：

Substances：

Year:  2023        PMID： 36255632     DOI： 10.1007/978-1-0716-2788-4_19

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  21 in total

1.  Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair.

Authors:  J R Walker; R A Corpina; J Goldberg
Journal:  Nature       Date:  2001-08-09       Impact factor: 49.962

2.  Pathways of DNA double-strand break repair during the mammalian cell cycle.

Authors:  Kai Rothkamm; Ines Krüger; Larry H Thompson; Markus Löbrich
Journal:  Mol Cell Biol       Date:  2003-08       Impact factor: 4.272

3.  Biochemical characterization of metnase's endonuclease activity and its role in NHEJ repair.

Authors:  Brian D Beck; Sung-Sook Lee; Elizabeth Williamson; Robert A Hromas; Suk-Hee Lee
Journal:  Biochemistry       Date:  2011-04-27       Impact factor: 3.162

Review 4.  The molecular basis and disease relevance of non-homologous DNA end joining.

Authors:  Bailin Zhao; Eli Rothenberg; Dale A Ramsden; Michael R Lieber
Journal:  Nat Rev Mol Cell Biol       Date:  2020-10-19       Impact factor: 94.444

Review 5.  Interstrand Crosslink Repair as a Target for HDAC Inhibition.

Authors:  Teodora Nikolova; Nicole Kiweler; Oliver H Krämer
Journal:  Trends Pharmacol Sci       Date:  2017-07-04       Impact factor: 14.819

Review 6.  The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway.

Authors:  Michael R Lieber
Journal:  Annu Rev Biochem       Date:  2010       Impact factor: 23.643

7.  DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells.

Authors:  Zhiyong Mao; Michael Bozzella; Andrei Seluanov; Vera Gorbunova
Journal:  Cell Cycle       Date:  2008-09-15       Impact factor: 4.534

8.  HDAC6 deacetylates and ubiquitinates MSH2 to maintain proper levels of MutSα.

Authors:  Mu Zhang; Shengyan Xiang; Heui-Yun Joo; Lei Wang; Kendra A Williams; Wei Liu; Chen Hu; Dan Tong; Joshua Haakenson; Chuangui Wang; Shengping Zhang; Ryan E Pavlovicz; Amanda Jones; Kristina H Schmidt; Jinfu Tang; Huiqin Dong; Bin Shan; Bin Fang; Rangasudhagar Radhakrishnan; Peter M Glazer; Patrick Matthias; John Koomen; Edward Seto; Gerold Bepler; Santo V Nicosia; Jiandong Chen; Chenglong Li; Liya Gu; Guo-Min Li; Wenlong Bai; Hengbin Wang; Xiaohong Zhang
Journal:  Mol Cell       Date:  2014-05-29       Impact factor: 17.970

Review 9.  DNA double-strand break repair-pathway choice in somatic mammalian cells.

Authors:  Ralph Scully; Arvind Panday; Rajula Elango; Nicholas A Willis
Journal:  Nat Rev Mol Cell Biol       Date:  2019-07-01       Impact factor: 113.915

10.  ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2.

Authors:  Andrea Beucher; Julie Birraux; Leopoldine Tchouandong; Olivia Barton; Atsushi Shibata; Sandro Conrad; Aaron A Goodarzi; Andrea Krempler; Penny A Jeggo; Markus Löbrich
Journal:  EMBO J       Date:  2009-09-24       Impact factor: 11.598
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