Literature DB >> 36255389

Cholesterol: Enhancing FGF2 translocation in unconventional secretion.

Haodong Wang1,2, Min Zhang3, Liang Ge1,2.   

Abstract

Fibroblast growth factor (FGF2) is a potent mitogen that is secreted through an unconventional secretory pathway by crossing the plasma membrane directly. In this current issue, Lolicato et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202106123) find that the secretion process is promoted by cholesterol, which enhances PI(4,5)P2 accessibility to FGF2 binding and alters membrane property to increase FGF2 translocation.
© 2022 Wang et al.

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Year:  2022        PMID： 36255389      PMCID： PMC9582227          DOI： 10.1083/jcb.202210007

Source DB:  PubMed          Journal:  J Cell Biol        ISSN： 0021-9525            Impact factor:   8.077


  9 in total

1.  Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β.

Authors:  Nicolas Dupont; Shanya Jiang; Manohar Pilli; Wojciech Ornatowski; Dhruva Bhattacharya; Vojo Deretic
Journal:  EMBO J       Date:  2011-11-08       Impact factor: 11.598

2.  Spontaneous and Stress-Induced Pore Formation in Membranes: Theory, Experiments and Simulations.

Authors:  Edel Cunill-Semanat; Jesús Salgado
Journal:  J Membr Biol       Date:  2019-07-30       Impact factor: 1.843

3.  Unconventional secretion of misfolded proteins promotes adaptation to proteasome dysfunction in mammalian cells.

Authors:  Jin-Gu Lee; Shokichi Takahama; Guofeng Zhang; Stanislav I Tomarev; Yihong Ye
Journal:  Nat Cell Biol       Date:  2016-06-13       Impact factor: 28.824

Review 4.  Intracellular Cholesterol Transport by Sterol Transfer Proteins at Membrane Contact Sites.

Authors:  Jie Luo; Lu-Yi Jiang; Hongyuan Yang; Bao-Liang Song
Journal:  Trends Biochem Sci       Date:  2018-11-08       Impact factor: 13.807

Review 5.  Unconventional secretion mediated by direct protein self-translocation across the plasma membranes of mammalian cells.

Authors:  Carola Sparn; Annalena Meyer; Roberto Saleppico; Walter Nickel
Journal:  Trends Biochem Sci       Date:  2022-04-27       Impact factor: 14.264

6.  The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages.

Authors:  Charles L Evavold; Jianbin Ruan; Yunhao Tan; Shiyu Xia; Hao Wu; Jonathan C Kagan
Journal:  Immunity       Date:  2017-11-28       Impact factor: 31.745

7.  Unconventional secretion of fibroblast growth factor 2 is mediated by direct translocation across the plasma membrane of mammalian cells.

Authors:  Tobias Schäfer; Hanswalter Zentgraf; Christoph Zehe; Britta Brügger; Jürgen Bernhagen; Walter Nickel
Journal:  J Biol Chem       Date:  2003-11-27       Impact factor: 5.157

8.  The LC3-conjugation machinery specifies the loading of RNA-binding proteins into extracellular vesicles.

Authors:  Andrew M Leidal; Hector H Huang; Timothy Marsh; Tina Solvik; Dachuan Zhang; Jordan Ye; FuiBoon Kai; Juliet Goldsmith; Jennifer Y Liu; Yu-Hsin Huang; Teresa Monkkonen; Ariadne Vlahakis; Eric J Huang; Hani Goodarzi; Li Yu; Arun P Wiita; Jayanta Debnath
Journal:  Nat Cell Biol       Date:  2020-01-13       Impact factor: 28.824

Review 9.  The glycosylphosphatidylinositol anchor: a complex membrane-anchoring structure for proteins.

Authors:  Margot G Paulick; Carolyn R Bertozzi
Journal:  Biochemistry       Date:  2008-06-17       Impact factor: 3.162
  9 in total

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