Literature DB >> 36243847

PI3K Isoforms in B Cells.

Elissa K Deenick1,2, Julia Bier3,4, Anthony Lau3,4.   

Abstract

Phosphatidylinositol-3-kinases (PI3K) control many aspects of cellular activation and differentiation and play an important role in B cells biology. Three different classes of PI3K have been described, all of which are expressed in B cells. However, it is the class IA PI3Ks, and the p110δ catalytic subunit in particular, which seem to play the most critical role in B cells. Here we discuss the important role that class IA PI3K plays in B cell development, activation and differentiation, as well as examine what is known about the other classes of PI3Ks in B cells.
© 2022. The Author(s), under exclusive license to Springer Nature Switzerland AG.

Entities:  

Keywords:  Antibody production; B cell development; B cells; Humoral immunity; PI3K

Mesh：

Substances：

Year:  2022        PMID： 36243847     DOI： 10.1007/978-3-031-06566-8_10

Source DB:  PubMed          Journal:  Curr Top Microbiol Immunol        ISSN： 0070-217X            Impact factor:   4.737


  101 in total

1.  The catalytic PI3K isoforms p110gamma and p110delta contribute to B cell development and maintenance, transformation, and proliferation.

Authors:  Sandra Beer-Hammer; Eva Zebedin; Max von Holleben; Judith Alferink; Bernhard Reis; Philipp Dresing; Daniel Degrandi; Stefanie Scheu; Emilio Hirsch; Veronika Sexl; Klaus Pfeffer; Bernd Nürnberg; Roland P Piekorz
Journal:  J Leukoc Biol       Date:  2010-03-03       Impact factor: 4.962

Review 2.  The intricate regulation and complex functions of the Class III phosphoinositide 3-kinase Vps34.

Authors:  Jonathan M Backer
Journal:  Biochem J       Date:  2016-08-01       Impact factor: 3.857

3.  B cell expression of the SH2-containing inositol 5-phosphatase (SHIP-1) is required to establish anergy to high affinity, proteinacious autoantigens.

Authors:  Janie Akerlund; Andrew Getahun; John C Cambier
Journal:  J Autoimmun       Date:  2015-07-04       Impact factor: 7.094

4.  Foxo1 directly regulates the transcription of recombination-activating genes during B cell development.

Authors:  Rupesh H Amin; Mark S Schlissel
Journal:  Nat Immunol       Date:  2008-05-11       Impact factor: 25.606

5.  Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function.

Authors:  Amy N Anzelon; Hong Wu; Robert C Rickert
Journal:  Nat Immunol       Date:  2003-02-03       Impact factor: 25.606

6.  Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage.

Authors:  Ivan Angulo; Oscar Vadas; Fabien Garçon; Edward Banham-Hall; Vincent Plagnol; Timothy R Leahy; Helen Baxendale; Tanya Coulter; James Curtis; Changxin Wu; Katherine Blake-Palmer; Olga Perisic; Deborah Smyth; Mailis Maes; Christine Fiddler; Jatinder Juss; Deirdre Cilliers; Gašper Markelj; Anita Chandra; George Farmer; Anna Kielkowska; Jonathan Clark; Sven Kracker; Marianne Debré; Capucine Picard; Isabelle Pellier; Nada Jabado; James A Morris; Gabriela Barcenas-Morales; Alain Fischer; Len Stephens; Phillip Hawkins; Jeffrey C Barrett; Mario Abinun; Menna Clatworthy; Anne Durandy; Rainer Doffinger; Edwin R Chilvers; Andrew J Cant; Dinakantha Kumararatne; Klaus Okkenhaug; Roger L Williams; Alison Condliffe; Sergey Nejentsev
Journal:  Science       Date:  2013-10-17       Impact factor: 47.728

7.  IL-21 promotes CD4 T cell responses by phosphatidylinositol 3-kinase-dependent upregulation of CD86 on B cells.

Authors:  Kesley Attridge; Rupert Kenefeck; Lukasz Wardzinski; Omar S Qureshi; Chun Jing Wang; Claire Manzotti; Klaus Okkenhaug; Lucy S K Walker
Journal:  J Immunol       Date:  2014-01-27       Impact factor: 5.422

8.  Inactivation of the Class II PI3K-C2β Potentiates Insulin Signaling and Sensitivity.

Authors:  Samira Alliouachene; Benoit Bilanges; Gaëtan Chicanne; Karen E Anderson; Wayne Pearce; Khaled Ali; Colin Valet; York Posor; Pei Ching Low; Claire Chaussade; Cheryl L Scudamore; Rachel S Salamon; Jonathan M Backer; Len Stephens; Phill T Hawkins; Bernard Payrastre; Bart Vanhaesebroeck
Journal:  Cell Rep       Date:  2015-11-19       Impact factor: 9.423

9.  Distinct roles for phosphoinositide 3-kinases γ and δ in malignant B cell migration.

Authors:  Ahmed Y Ali; Xun Wu; Nour Eissa; Sen Hou; Jean-Eric Ghia; Thomas T Murooka; Versha Banerji; James B Johnston; Francis Lin; Spencer B Gibson; Aaron J Marshall
Journal:  Leukemia       Date:  2018-01-31       Impact factor: 11.528

10.  Germline-activating mutations in PIK3CD compromise B cell development and function.

Authors:  Danielle T Avery; Alisa Kane; Tina Nguyen; Anthony Lau; Akira Nguyen; Helen Lenthall; Kathryn Payne; Wei Shi; Henry Brigden; Elise French; Julia Bier; Jana R Hermes; David Zahra; William A Sewell; Danyal Butt; Michael Elliott; Kaan Boztug; Isabelle Meyts; Sharon Choo; Peter Hsu; Melanie Wong; Lucinda J Berglund; Paul Gray; Michael O'Sullivan; Theresa Cole; Steven M Holland; Cindy S Ma; Christoph Burkhart; Lynn M Corcoran; Tri Giang Phan; Robert Brink; Gulbu Uzel; Elissa K Deenick; Stuart G Tangye
Journal:  J Exp Med       Date:  2018-07-17       Impact factor: 14.307
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